Target Name: RNF19A
NCBI ID: G25897
Review Report on RNF19A Target / Biomarker Content of Review Report on RNF19A Target / Biomarker
RNF19A
Other Name(s): p38 | RING finger protein 19 isoform | OTTHUMP00000227364 | P38 | Ring-IBR-ring domain containing protein Dorfin | ring finger protein 19A, RBR E3 ubiquitin protein ligase | RN19A_HUMAN | protein p38 interacting with transcription factor Sp1 | E3 ubiquitin-protein ligase RNF19A | double ring-finger protein | Protein p38 interacting with transcription factor Sp1 | P38 protein | Dorfin | DKFZp566B1346 | ring-IBR-ring domain containing protein Dorfin | Ring finger protein 19A, RBR E3 ubiquitin protein ligase, transcript variant 1 | RING finger protein 19A | keratin, type II cytoskeletal 2 epidermal-like | RNF19A variant 1 | RNF19 | Double ring-finger protein | ring finger protein 19A, E3 ubiquitin protein ligase | DORFIN | OTTHUMP00000227271

Unique RNA Molecule with Potential as Drug Target and Biomarker

RNA-Fucose-157 (RNF19A) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure, which consists of a single RNA molecule and a distinct N-terminal region that is rich in conserved secondary structure elements, has made it a promising candidate for drug targeting.

The N-terminal region of RFN19A contains a conserved sequence that is commonly found in various RNA molecules, known as the unitary stem-loop. This stem-loop is a structural element that is composed of a series of alternating A/U and G/ C base pairs, which can form a hairpin loop that can bind to specific DNA sequences. The conserved sequence in the N-terminal region of RFN19A is similar to that of the unitary stem-loop found in other RNA molecules, such as microRNA (miRNA ) and small interfering RNA (siRNA).

The unique feature of RFN19A is its ability to form a stable hairpin loop in the N-terminal region, which can interact with specific DNA sequences in the cell. This interaction between RFN19A and DNA has led to its potential as a drug target. The N -terminal region of RFN19A has been shown to interact with several transcription factors, including NF-kappa-B, AP-1, and NF-Y2. These transcription factors are involved in various cellular processes that are important for the development, maintenance, and progression of various diseases. By targeting these transcription factors, RFN19A may be able to modulate their activity and contribute to the pathogenesis of these diseases.

In addition to its potential as a drug target, RFN19A has also been identified as a potential biomarker for various diseases. The conserved N-terminal region of RFN19A has been shown to be expressed in a variety of tissues and fluids, including blood, saliva, urine, and tissue samples from cancer patients. This suggests that RFN19A may be a useful biomarker for the diagnosis and monitoring of cancer. Additionally, the stable hairpin loop in the N-terminal region of RFN19A may also be useful as a biomarker for certain neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

The unique structure of RFN19A has also made it a promising candidate for drug targeting in other contexts. For example, the conserved N-terminal region of RFN19A has been shown to interact with several protein kinases, including casein kinase (CK) and tyrosine kinase ( TK). These protein kinases are involved in various cellular processes that are important for the development and progression of diseases. By targeting these protein kinases, RFN19A may be able to modulate their activity and contribute to the pathogenesis of these diseases.

In conclusion, RFN19A is a promising candidate for drug targeting and biomarker due to its unique structure and its ability to form a stable hairpin loop in the N-terminal region. The conserved N-terminal region has been shown to interact with several transcription factors and protein kinases, which may be potential targets for drugs that are aimed at treating various diseases. Further research is needed to fully understand the unique mechanisms of RFN19A and its potential as a drug target and biomarker.

Protein Name: Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection

The "RNF19A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF19A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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