TSKU: A Potential Drug Target for Neurological Disorders (G25987)

Target Name: TSKU

NCBI ID: G25987

TSKU

TSKU: A Potential Drug Target for Neurological Disorders

TSKU, short for tubulin synaptic protein, is a protein that plays a crucial role in the structure and function of neural synapses. It is a transmembrane protein that forms the cytoskeleton and is involved in the regulation of cell division, differentiation, and neurotransmitter release.

Recent studies have identified TSKU as a potential drug target for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. The exact mechanism of how TSKU contributes to these disorders is not yet fully understood, but its involvement in their development is clear.

One of the key mechanisms through which TSKU contributes to neurological disorders is its role in the regulation of neurotransmitter release. Neurons in the brain release chemical messengers, called neurotransmitters, to communicate with each other and with the rest of the body. The release of these Neurotransmitters are regulated by a complex series of proteins, including TSKU.

Research has shown that TSKU plays a critical role in the regulation of neurotransmitter release by affecting the trafficking of neurotransmitter-producing neurons to and from the cell body. This is important for maintaining the proper functioning of the brain and for the regulation of neurotransmission.

Another mechanism through which TSKU contributes to neurological disorders is its role in the regulation of cell division and differentiation. Neurons are highly specialized cells that divide and differentiate into specific types of cells that are responsible for transmitting electrical signals throughout the body. division and differentiation is critical for the development and maintenance of the nervous system, and TSKU is involved in this process.

Research has shown that TSKU plays a critical role in the regulation of cell division and differentiation by affecting the production of new neurons and the maintenance of the integrity of existing neurons. This is important for the development and maintenance of the nervous system and for the regulation of neurotransmission.

In addition to its role in the regulation of neurotransmission and cell division and differentiation, TSKU has also been shown to be involved in the regulation of other processes that are important for the proper functioning of the brain. For example, TSKU has been shown to play a critical role in the regulation of ion channels in neural cells, which are responsible for the flow of electrical signals through the cell.

The identification of TSKU as a potential drug target for neurological and psychiatric disorders has led to a great deal of interest and research in this area. Further studies are needed to fully understand the role of TSKU in these disorders and to develop effective treatments. By targeting TSKU with small molecules or other therapeutic agents, researchers hope to improve the treatment options available for a variety of neurological and psychiatric disorders.

Protein Name: Tsukushi, Small Leucine Rich Proteoglycan

Functions: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis

The "TSKU Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TSKU comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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