Traf3ip1: A Cancer-Related Protein with Potential Drug Targets

Target Name: TRAF3IP1

NCBI ID: G26146

TRAF3IP1

Traf3ip1: A Cancer-Related Protein with Potential Drug Targets

Traf3ip1 (SLSN9) is a protein that is expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein synthesis. It is a key player in the Signal Transduction Network (STN), which is a complex of proteins that transduction Signaling molecules inside and outside cells. Traf3ip1 regulates protein synthesis by binding to and activating receptors in the STN.

Activation of Traf3ip1 requires binding to receptors in the STN, including SMAD, SPOP and TAPI2. By binding to these receptors, Traf3ip1 can activate transduction cascades in the STN, leading to protein synthesis and modification. Activation of Traf3ip1 may also lead to chromatin remodeling and affect gene expression.

Traf3ip1 plays an important role in various cancers. In lung cancer, Traf3ip1 activation is positively correlated with treatment response. In breast cancer, the activation of Traf3ip1 is positively correlated with the incidence of Erda syndrome. In neuroblastoma, Traf3ip1 activation is positively correlated with chemotherapy sensitivity.

Activation of Traf3ip1 also interacts with many proteins, including HSP70, HSP90 and HSP100. These proteins can affect the stability of Traf3ip1, thereby affecting its function.

Traf3ip1 is a very attractive drug target because it is associated with the pathogenesis of various cancers. Activation of Traf3ip1 may also be an important biomarker that can help doctors diagnose and predict disease progression in patients.

Protein Name: TRAF3 Interacting Protein 1

Functions: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity)

The "TRAF3IP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAF3IP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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