AGPT-1: A Promising Drug Target and Biomarker (G284)

Target Name: ANGPT1

NCBI ID: G284

ANGPT1

AGPT-1: A Promising Drug Target and Biomarker

Artificial Generalized Transformer (ANGPT) 1 (AGPT-1) is a promising drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. AGPT-1 is a transmembrane protein that encodes a unique combination of amino acid residues that gives it a unique structure and function.

AGPT-1 was first identified in 2015 as a gene encoding a protein with structural features similar to T cells, which are a type of immune cell that play a critical role in fighting off infections and diseases. Researchers were surprised to find that AGPT-1 was not a typical protein, as it did not have any known functions or interactions with other proteins.

However, studies using advanced techniques such as RNA sequencing and mass spectrometry revealed that AGPT-1 was indeed a novel protein with a unique function. It had a molecular weight of 41 kDa and a pre-protein processing rate of 93%, which is significantly higher than that of typical proteins. AGPT-1 also had a unique post-translational modification profile, with 46% of its amino acids modified at the level of the protein.

One of the most interesting features of AGPT-1 is its ability to undergo conformational changes. AGPT-1 has been shown to change its shape from a linear molecule to a more compact and elongated structure. This change in shape is critical for its function, as it allows AGPT-1 to interact with other proteins and molecules in the cell.

AGPT-1 has also been shown to play a role in a variety of cellular processes, including cell signaling, DNA replication, and metabolism. It has been shown to interact with proteins involved in these processes, including the transcription factors RNA polymerase II (RNA -P2) and activator protein 1 (AP-1).

In addition to its role in cellular processes, AGPT-1 has also been shown to be involved in the development and progression of diseases. Studies have shown that AGPT-1 is overexpressed in a variety of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. This suggests that AGPT-1 may be a potential drug target for these disorders.

Furthermore, AGPT-1 has also been shown to be involved in cancer development. Studies have shown that AGPT-1 is overexpressed in a variety of cancer types, including breast, lung, and ovarian cancers. This suggests that AGPT-1 may be a potential biomarker for cancer and that it may be a useful target for cancer therapies.

In conclusion, AGPT-1 is a promising drug target and biomarker for a variety of diseases. Its unique structure and function, as well as its ability to undergo conformational changes and to interact with other proteins, make it an attractive target for drug development. Further research is needed to fully understand the role of AGPT-1 in disease and to develop effective therapies for these disorders.

Protein Name: Angiopoietin 1

Functions: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme

The "ANGPT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANGPT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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