CISD3: A promising drug target for the treatment of chronic diseases

Target Name: CISD3

NCBI ID: G284106

CISD3

CISD3: A promising drug target for the treatment of chronic diseases

Abstract:

Chronic diseases such as diabetes, heart disease, and neurodegenerative disorders have become a significant public health issue worldwide, affecting millions of people. The development of effective therapies for these diseases remains a major challenge. CISD3, a protein found in the mitochondria, has been identified as a potential drug target for the treatment of chronic diseases. This article will discuss the structure and function of CISD3, its potential as a drug target, and the current research on its clinical applications.

Introduction:

Chronic diseases have a significant impact on human health and quality of life. These diseases, including diabetes, heart disease, and neurodegenerative disorders, can be caused by a range of factors, including genetic and environmental factors. The development of effective therapies for these diseases remains a major challenge, and the search for new treatments has led to the exploration of various protein structures and their functions. CISD3, a protein found in the mitochondria, has been identified as a potential drug target for the treatment of chronic diseases.

Structure and Function:

CISD3 is a protein that contains a domain-containing iron-sulfur complex (CISD3-FS) and is located in the mitochondria. It has a molecular weight of approximately 36 kDa and a pre-protein N-terminus of 21 amino acids. CISD3- FS consists of an N-terminal domain with a conserved core domain, a central transmembrane domain, and an C-terminal domain with a unique iron-sulfur configuration.

The CISD3-FS domain is a conserved region that is present in various proteins, including CISD3, Apolipoprotein A-1 (APA1), and Superoxide Dismutase 1 (SOD1). This domain is known as the \"F-type ion transmembrane domain\ " and is characterized by the presence of a hypervariable region (HVR) that is involved in the transfer of electrical charge across the membrane. The HVR is composed of a long alpha-helices and a variable beta-sheet that are involved in the formation of a transmembrane pocket.

The CISD3-FS domain is also known for its unique iron-sulfur configuration. Cisiotinium ions are introduced into the CISD3-FS domain through a specific cysteine 鈥嬧?媟esidue, which allows the domain to form a stable complex with sulfur dioxide, resulting in the formation of a Cu2+-S2O32- ion pair. This ion pair is then involved in the production of reactive oxygen species (ROS), which can cause damage to cellular components and contribute to the development of chronic diseases.

CISD3 has been shown to play a significant role in the development and progression of various chronic diseases. For example, studies have shown that CISD3 levels are increased in individuals with type 2 diabetes and that inhibition of CISD3 has been shown to improve insulin sensitivity and reduce the risk of cardiovascular disease. Additionally, CISD3 has also been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Potential Therapeutic Applications:

The unique iron-sulfur configuration of CISD3 makes it a promising drug target for the treatment of chronic diseases. The production of ROS by the CISD3-FS domain can be inhibited, which can reduce the risk of cellular damage and the progression of chronic diseases.

One potential approach to inhibiting CISD3 is through the use of small molecules. Chemical compounds that can inhibit the production of ROS by the CISD3-FS domain could be developed as potential therapeutic agents for the treatment of chronic diseases. Currently, several studies are being conducted to identify small molecules that can inhibit

Protein Name: CDGSH Iron Sulfur Domain 3

Functions: Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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