ZNF750: A Key Regulator of Neural Development and Function (G79755)
ZNF750: A Key Regulator of Neural Development and Function
ZNF750 (ZN750_HUMAN), a protein encoded by the ZNF7 gene, is a key regulator of neural development and function. The ZNF7 gene is located on chromosome 6p21.1 and has been implicated in various neurological and psychiatric disorders, including schizophrenia, bipolar disorder, and Alzheimer's disease. ZNF750 has been shown to play a crucial role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.
The ZNF7 gene is a member of the ZNF family, which includes several similar genes that are involved in the regulation of neural development and function. The ZNF7 gene is characterized by the presence of a unique N-terminal region that contains a conserved nuclear localization signal (NLS) and a transmembrane domain. The NLS is a protein-coding region that is involved in the regulation of nuclear transport and has been implicated in the regulation of various cellular processes, including cell adhesion, migration, and invasion.
ZNF7 is expressed in various tissues and cells of the body, including the brain, where it is involved in the regulation of synaptic plasticity, neurotransmitter release, and cell survival. ZNF7 has been shown to play a role in the regulation of synaptic plasticity by modulating the activity of several transcription factors, including Dopamine-dependent neuronal plasticity (DAP-N) and GABA-regulated synaptic plasticity (GABASyn) transcription factors.
In addition to its role in synaptic plasticity, ZNF7 has also been shown to play a role in the regulation of neuronal differentiation and cell survival. ZNF7 has been shown to promote the survival of neuronal cells by modulating the activity of several cell survival factors, including Bcl-2 (Bcl-2 gene), which is a protein that is involved in the regulation of cell apoptosis (programmed cell death).
The ZNF7 gene has also been implicated in the regulation of various psychiatric and neurological disorders, including schizophrenia, bipolar disorder, and Alzheimer's disease. Several studies have shown that individuals with schizophrenia and bipolar disorder are characterized by reduced levels of ZNF7 in certain brain regions. Additionally, ZNF7 has been shown to be involved in the regulation of neurotransmitter release in individuals with Alzheimer's disease, which is a leading cause of dementia.
In conclusion, ZNF750 (ZN750_HUMAN) is a protein that is involved in the regulation of various cellular processes, including synaptic plasticity, neuronal differentiation, and cell survival. Its role in these processes is likely to be a drug target or biomarker for the treatment of psychiatric and neurological disorders. Further research is needed to fully understand the role of ZNF750 in these processes and to develop effective treatments for psychiatric and neurological disorders.
Protein Name: Zinc Finger Protein 750
Functions: Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression
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More Common Targets
ZNF75A | ZNF75CP | ZNF75D | ZNF76 | ZNF761 | ZNF763 | ZNF764 | ZNF765 | ZNF766 | ZNF767P | ZNF768 | ZNF77 | ZNF770 | ZNF771 | ZNF772 | ZNF773 | ZNF774 | ZNF775 | ZNF776 | ZNF777 | ZNF778 | ZNF780A | ZNF780B | ZNF781 | ZNF782 | ZNF783 | ZNF784 | ZNF785 | ZNF786 | ZNF787 | ZNF788P | ZNF789 | ZNF79 | ZNF790 | ZNF790-AS1 | ZNF791 | ZNF792 | ZNF793 | ZNF799 | ZNF8 | ZNF8-ERVK3-1 | ZNF80 | ZNF800 | ZNF804A | ZNF804B | ZNF805 | ZNF807P | ZNF808 | ZNF81 | ZNF812P | ZNF813 | ZNF814 | ZNF815P | ZNF816 | ZNF816-ZNF321P | ZNF818P | ZNF821 | ZNF823 | ZNF826P | ZNF827 | ZNF829 | ZNF83 | ZNF830 | ZNF831 | ZNF833P | ZNF835 | ZNF836 | ZNF837 | ZNF839 | ZNF839P1 | ZNF84 | ZNF840P | ZNF841 | ZNF843 | ZNF844 | ZNF845 | ZNF846 | ZNF85 | ZNF850 | ZNF852 | ZNF853 | ZNF860 | ZNF862 | ZNF865 | ZNF875 | ZNF876P | ZNF878 | ZNF879 | ZNF880 | ZNF883 | ZNF887P | ZNF888 | ZNF890P | ZNF891 | ZNF90 | ZNF91 | ZNF92 | ZNF93 | ZNF962P | ZNF98
