Target Name: ZNF738
NCBI ID: G148203
Review Report on ZNF738 Target / Biomarker Content of Review Report on ZNF738 Target / Biomarker
ZNF738
Other Name(s): zinc finger protein 738 | ZNF738 variant 2 | Zinc finger protein 738, transcript variant 2 | protein ZNF738 | Protein ZNF738 | ZN738_HUMAN

ZNF738: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including gene regulation, DNA replication, and cell signaling. ZNF738, a ZFP that is expressed in various tissues and cells, has been identified as a potential drug target and biomarker.

The ZNF738 Protein

ZNF738 is a 21-kDa protein that is expressed in various tissues, including brain, heart, liver, and pancreas. It is composed of a unique nucleotide-binding oligomerization (NBO) domain that consists of a nucleotide-binding domain and a C-terminal hypervariable region (HVR). The NBO domain is responsible for the protein's nucleotide-binding affinity, while the HVR is involved in the protein's stability and hypervariable interactions.

Function and Interactions

ZNF738 is involved in various cellular processes, including cell signaling, DNA replication, and gene regulation. It is a key regulator of the T-cell receptor (TCR), which is a critical element of adaptive immunity. ZNF738 has been shown to play a role in the regulation of TCR-mediated immunity, cell cycle progression, and apoptosis.

In addition to its role in TCR signaling, ZNF738 is also involved in the regulation of DNA replication and cell signaling. It has been shown to interact with various DNA-binding proteins, including the tumor suppressor protein p53. p53 is a well-known protein that plays a critical role in the regulation of DNA replication, and it has been shown to interact with ZNF738.

Potential Drug Target

The ZNF738 protein is a potential drug target due to its various functions in cellular processes. One of the main reasons for its potential as a drug target is its involvement in TCR signaling. TCR-mediated immunity is a critical element of adaptive immunity, and targeting TCR signaling has been shown to be effective in treating various types of cancer.

Another potential mechanism by which ZNF738 could be targeted is its role in the regulation of DNA replication. DNA replication is a critical process that is involved in the development and maintenance of cancer. Therefore, inhibiting ZNF738's function in DNA replication could be an effective way to treat cancer.

Biomarker Potential

ZNF738 has also been identified as a potential biomarker for various types of cancer. The ZNF738 protein is expressed in various tissues, including cancer cells, and its levels have been shown to be elevated in these cells. This suggests that ZNF738 could be used as a biomarker for cancer diagnosis and monitoring.

In addition to its potential as a drug target and biomarker, ZNF738 is also involved in the regulation of various cellular processes, including cell signaling and DNA replication. Its unique NBO domain and HVR make it a unique protein that could be targeted with small molecules or antibodies.

Conclusion

ZNF738 is a protein that is involved in various cellular processes, including cell signaling, DNA replication, and TCR signaling. Its unique NBO domain and HVR make it a unique protein that could be targeted with small molecules or antibodies. The ZNF738 protein is expressed in various tissues and has been shown to play a role in the regulation of TCR-mediated immunity, DNA replication, and cell signaling. Therefore, ZNF738 is a potential drug target and biomarker for various types of cancer. Further research is needed to fully understand its functions and potential uses in medical treatment.

Protein Name: Zinc Finger Protein 738

Functions: May be involved in transcriptional regulation

The "ZNF738 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF738 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZNF74 | ZNF740 | ZNF746 | ZNF747 | ZNF749 | ZNF750 | ZNF75A | ZNF75CP | ZNF75D | ZNF76 | ZNF761 | ZNF763 | ZNF764 | ZNF765 | ZNF766 | ZNF767P | ZNF768 | ZNF77 | ZNF770 | ZNF771 | ZNF772 | ZNF773 | ZNF774 | ZNF775 | ZNF776 | ZNF777 | ZNF778 | ZNF780A | ZNF780B | ZNF781 | ZNF782 | ZNF783 | ZNF784 | ZNF785 | ZNF786 | ZNF787 | ZNF788P | ZNF789 | ZNF79 | ZNF790 | ZNF790-AS1 | ZNF791 | ZNF792 | ZNF793 | ZNF799 | ZNF8 | ZNF8-ERVK3-1 | ZNF80 | ZNF800 | ZNF804A | ZNF804B | ZNF805 | ZNF807P | ZNF808 | ZNF81 | ZNF812P | ZNF813 | ZNF814 | ZNF815P | ZNF816 | ZNF816-ZNF321P | ZNF818P | ZNF821 | ZNF823 | ZNF826P | ZNF827 | ZNF829 | ZNF83 | ZNF830 | ZNF831 | ZNF833P | ZNF835 | ZNF836 | ZNF837 | ZNF839 | ZNF839P1 | ZNF84 | ZNF840P | ZNF841 | ZNF843 | ZNF844 | ZNF845 | ZNF846 | ZNF85 | ZNF850 | ZNF852 | ZNF853 | ZNF860 | ZNF862 | ZNF865 | ZNF875 | ZNF876P | ZNF878 | ZNF879 | ZNF880 | ZNF883 | ZNF887P | ZNF888 | ZNF890P | ZNF891