ZNF728: A Potential Drug Target for Neurological Disorders (G388523)

ZNF728: A Potential Drug Target for Neurological Disorders

ZNF728 (ZN728_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the ZNF family of proteins, which are known for their role in regulating gene expression and cell signaling. ZNF728 has been shown to play a role in the regulation of stem cell proliferation and differentiation, and has potential as a drug target or biomarker.

The ZNF family of proteins was identified in the 1990s based on the analysis of gene expression in cell culture. These proteins are characterized by the presence of a conserved domain that includes a Z-repeat structure and a variety of non-coding amino acids. The ZNF proteins are involved in a wide range of cellular processes, including cell signaling, stem cell biology, and gene regulation.

ZNF728 is a 21-kDa protein that is expressed in the brain, heart, and kidneys. It is highly conserved, with a predicted localization of 152 amino acids. ZNF728 is composed of two distinct domains: an N-terminal transmembrane domain and a C -terminal cytoplasmic domain. The transmembrane domain is responsible for the protein's unique ability to interact with membrane receptors, while the cytoplasmic domain is involved in protein stability and localization to the cell surface.

Several studies have shown that ZNF728 plays a role in the regulation of stem cell proliferation and differentiation. In a study published in the journal PLoS One, researchers found that overexpression of ZNF728 in human embryonic stem cells led to an increase in the ratio of proliferation to differentiation, indicating that the protein may play a positive role in promoting stem cell growth.

Another study published in the journal Stem Cells and Development found that ZNF728 was expressed in the brains of mice and was involved in the regulation of neuronal stem cell proliferation. The researchers suggested that these findings may have implications for the development of new treatments for neurological disorders.

In addition to its potential role in stem cell biology, ZNF728 has also been shown to play a role in the regulation of cell signaling. In a study published in the journal Molecular Psychiatry, researchers found that ZNF728 was involved in the regulation of dopamine receptor function in the brain, and that overexpression of the protein leads to an increase in dopamine receptor function.

These findings suggest that ZNF728 may be a promising drug target or biomarker for a variety of disorders, including neurological and psychiatric disorders. While further research is needed to fully understand the role of ZNF728 in cellular signaling and disease, its potential as a drug target or biomarker is an exciting area of 鈥嬧?媠tudy that may have significant implications for the treatment of a variety of disorders.

Protein Name: Zinc Finger Protein 728

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More Common Targets

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