TRBV28: A Potential Drug Target and Biomarker for T Cell Receptor尾 Variants

Target Name: TRBV28

NCBI ID: G28559

TRBV28

Other Name(s): T cell receptor beta variable 28 | TCRBV28S1 | TCRBV3S1

TRBV28: A Potential Drug Target and Biomarker for T Cell Receptor尾 Variants

T cells are a crucial part of the immune system, and their function is critical for protecting the body against infection and disease. T cells are characterized by their ability to recognize and respond to foreign antigens, which is a critical aspect of their immune response. The T cell receptor (TCR), also known as T cell receptor beta variable 28 (TRBV28), is a key molecule that plays a crucial role in this process.

TRBV28 is a transmembrane protein that is expressed in T cells, and it is involved in the recognition of foreign antigens. It is a single-pass receptor that consists of a variable region and a constant region. The variable region of TRBV28 consists of two hypervariable regions (HVRs), which are responsible for the recognition of different antigens.

One of the HVRs of TRBV28 is known as HVR-A, which consists of a single amino acid residue at its C-terminus. HVR-A is involved in the recognition of a specific antigen, known as alloantigen, which is self-antigen that the body produces. The recognition of alloantigens is critical for the development of self-reactive diseases, such as autoimmune diseases.

Another HVR of TRBV28 is known as HVR-B, which consists of a single amino acid residue at its N-terminus. HVR-B is involved in the recognition of foreign antigens, such as viruses and bacteria. The recognition of foreign antigens is critical for the development of adaptive immunity, which is the ability of the immune system to respond to foreign antigens.

TRBV28 is a critical molecule in the immune system because it is involved in the recognition of both self-antigens and foreign antigens. However, there are several variants of TRBV28 that have been identified, and the function and importance of each variant is not yet fully understood.

One of the variants of TRBV28 is known as TRBV28-ASP, which has been shown to be involved in the regulation of T cell responses. TRBV28-ASP is a 21-kDa protein that is expressed in T cells and is involved in the regulation of the development and function of T cells.

Another variant of TRBV28 is known as TRBV28-FQ, which has been shown to be involved in the regulation of T cell responses and has been identified as a potential drug target. TRBV28-FQ is a 120-kDa protein that is expressed in T cells and is involved in the regulation of the development and function of T cells.

In addition to its role in T cell regulation, TRBV28 has also been shown to be involved in the development of cancer. Several studies have shown that TRBV28 is involved in the regulation of cell proliferation and has been identified as a potential biomarker for cancer.

The importance of TRBV28 is not limited to its role in T cell regulation and cancer development. It is also involved in the regulation of other cellular processes, such as cell adhesion, migration, and apoptosis.

In conclusion, TRBV28 is a critical molecule in the immune system that is involved in the recognition of both self-antigens and foreign antigens. The function and importance of TRBV28 variants, such as TRBV28-ASP and TRBV28-FQ, are not yet fully understood, and further research is needed to fully

Protein Name: T Cell Receptor Beta Variable 28

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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