TRBV4-2: A Potential Drug Target and Biomarker for T Cell Receptor Beta Variant 4.2

Target Name: TRBV4-2

NCBI ID: G28616

TRBV4-2

TRBV4-2: A Potential Drug Target and Biomarker for T Cell Receptor Beta Variant 4.2

T cells are a crucial part of the immune system, and their role in fighting off infections and diseases is critical for maintaining human health. T cells are able to recognize and respond to specific antigens, which is crucial for fighting off diseases and maintaining a healthy immune system. One of the proteins that T cells use to recognize these antigens is called T cell receptor beta variable 4-2 (TRBV4-2).

TRBV4-2 is a protein that is found on the surface of T cells. It is a type of receptor that is known as a co-stimulatory receptor, which means that it works with other proteins to stimulate the activity of the T cell. -2 is also a critical protein for regulating the activity of T cells, and it is involved in a number of different processes that are important for immune function.

One of the things that makes TRBV4-2 such an important protein is its role in regulating the activity of T cells. T cells are a vital part of the immune system, and they are responsible for fighting off infections and diseases. In order to do this, T cells need to be activated and able to recognize and respond to specific antigens. TRBV4-2 plays a key role in regulating the activity of T cells by helping them to recognize and respond to the presence of an antigen.

Another important function of TRBV4-2 is its role in regulating the activity of T cells in the context of an infection or disease. When an T cell is infected with a specific virus or bacteria, TRBV4-2 helps the cell to recognize and respond to the presence of that virus or bacteria. This is crucial for fighting off the infection and preventing it from causing further damage.

In addition to its role in regulating T cell activity, TRBV4-2 is also involved in a number of other processes that are important for immune function. For example, TRBV4-2 is involved in the regulation of T cell proliferation, which is the process by which T cells are able to grow and divide. It is also involved in the regulation of T cell death, which is important for ensuring that T cells are able to respond to an infection or disease.

TRBV4-2 is also a protein that is involved in the regulation of the immune response. It is able to help T cells to recognize and respond to the presence of an antigen, which is crucial for fighting off the infection or disease. It is also involved in the regulation of the production of antibodies, which are proteins that are able to neutralize toxins and other harmful substances.

In conclusion, TRBV4-2 is a protein that is involved in a number of important functions for T cells. It plays a key role in regulating T cell activity, and it is also involved in the regulation of T cell death and the immune response. As a result, TRBV4-2 may be a valuable drug target or biomarker for researchers who are trying to develop new treatments for diseases. By targeting TRBV4-2, researchers may be able to develop new treatments that are effective in fighting off infections and diseases .

Protein Name: T Cell Receptor Beta Variable 4-2

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBV4-2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBV4-2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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