Trajectory-14DV4: A Protein with Multiple Functions in The Body

Target Name: TRAV14DV4

NCBI ID: G28669

TRAV14DV4

Other Name(s): TRAV14/DV4 | hADV14S1 | T cell receptor alpha variable 14/delta variable 4 | TCRAV6S1-hDV104S1

Trajectory-14DV4: A Protein with Multiple Functions in The Body

Trajectory 14DV4, also known as Trajectory-14DV4, is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the Tetraspanin family, which are a group of proteins that are Characterized by the presence of a unique nucleotide-rich region on their cell surfaces.

The Trajectory-14DV4 protein is of particular interest because it has been shown to play a role in a variety of physiological processes in the body. One of the most significant functions of Trajectory-14DV4 is its role in the regulation of cell migration. This protein is involved in the formation of the mitotic spindle, which is the structure that pulls the chromosomes apart during cell division.

In addition to its role in cell migration, Trajectory-14DV4 has also been shown to play a role in the regulation of cell adhesion. This protein is involved in the formation of tight junctions, which are the structures that mediate the transfer of electrical signals between cells.

Trajectory-14DV4 has also been shown to play a role in the regulation of ion channels. This protein is involved in the regulation of the potassium and sodium channels on the surface of cells, which are responsible for the flow of electrical signals through the cell.

In addition to its role in the regulation of cell migration, Trajectory-14DV4 has also been shown to play a role in the regulation of cell survival. This protein is involved in the regulation of the Bcl-2 protein, which is a protein that has been shown to play a role in the regulation of cell survival.

Trajectory-14DV4 has also been shown to play a role in the regulation of inflammation. This protein is involved in the regulation of the NF-kappa-B signaling pathway, which is a complex that is involved in the regulation of inflammation.

In conclusion, Trajectory-14DV4 is a protein that has been shown to play a role in a variety of physiological processes in the body. Its role in the regulation of cell migration, adhesion, ion channels, cell survival, and inflammation makes it an attractive target for further research. Further studies are needed to fully understand the functions of Trajectory-14DV4 and its potential as a drug or biomarker.

Protein Name: T Cell Receptor Alpha Variable 14/delta Variable 4

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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