HNF4A: Key Regulator of Gene Expression and Potential Drug Target

Target Name: HNF4A

NCBI ID: G3172

HNF4A

HNF4A: Key Regulator of Gene Expression and Potential Drug Target

HNF4A, also known as HNF4A gene, is a gene that encodes a protein known as the homeobox gene family 4A (HNF4A). The HNF4A gene is a member of the family of transcription factors, which are a group of proteins that regulate gene expression. HNF4A is a key regulator of gene expression in many organisms, including humans.

The HNF4A gene is located on chromosome 11p36 and has been implicated in a number of important biological processes. One of the most well-studied functions of HNF4A is its role in the development and progression of many diseases, including cancer. HNF4A has also been shown to play a key role in the regulation of stem cell proliferation and the development of tissues such as skin, hair and nails.

In addition to its role in disease, HNF4A has also been shown to be a potential drug target. Researchers have identified several potential drug targets for HNF4A, including those that interact with the protein in different ways. One of the most promising potential drug targets for HNF4A is the use of small molecules, such as those derived from natural products, to inhibit the activity of HNF4A and its downstream targets.

Another potential drug target for HNF4A is the use of inhibitors of the HNF4A- transcription factor complex, which includes the protein itself as well as several other proteins that are regulated by HNF4A. These inhibitors have been shown to be effective in cell culture and animal models of disease, and may be a useful tool for the treatment of certain diseases.

In conclusion, HNF4A is a gene that has been shown to play a key role in the development and progression of many diseases, including cancer. It is also a potential drug target, with several potential inhibitors that have been shown to be effective in cell culture and animal models of disease. Further research is needed to fully understand the role of HNF4A in disease and to develop effective treatments for those diseases.

Protein Name: Hepatocyte Nuclear Factor 4 Alpha

Functions: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)

The "HNF4A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HNF4A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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