Discovering The Function of HOOK3: A Key Protein in Cell Signaling and Neuroscience

Target Name: HOOK3

NCBI ID: G84376

HOOK3

Discovering The Function of HOOK3: A Key Protein in Cell Signaling and Neuroscience

The word Hoekstrate comes from the Greek word meaning "hook", indicating a curved shape. In the field of biology, the term hoekstrate usually refers to a protein that has the function of guiding biological macromolecules such as molecules, enzymes, or ligands. FLJ31058 is a fluorescent protein with a similar shape, hence the name HOOK3.

HOOK3 (FLJ31058) is a fluorescent protein developed by the American pharmaceutical company Roche. It is a protein used in the study of cell signal transduction, cell metabolism and cell biology processes. HOOK3 plays important roles in a variety of tissues and biological processes, providing scientists with a powerful tool to study these processes.

The discovery of HOOK3 originated from the study of cell signal transduction processes. In cells, signaling molecules transmit information through a complex series of interactions to regulate various biological processes. HOOK3 plays a key role in this process, serving as a receptor for signaling molecules. By studying the function of HOOK3, scientists can better understand the molecular mechanism of cell signal transduction and provide new clues for the treatment of various diseases.

HOOK3's application in cancer research is particularly compelling. As a receptor for signaling molecules, HOOK3 can be used to study the growth, division and survival of cancer cells. Scientists have discovered that the expression levels of HOOK3 are different in various cancers, which provides new targets for cancer diagnosis, prediction and treatment. By modulating the function of HOOK3, scientists can design more effective cancer treatment strategies and improve patient survival rates.

HOOK3 also plays an important role in the field of neuroscience. Neurons are the basic units of the nervous system, and HOOK3 plays a key role in this process as a regulator of neuronal activity. By studying the function of HOOK3, scientists can better understand the working mechanism of neurons, providing new clues for the treatment of neurodegenerative diseases.

In addition, HOOK3 is also widely used in other fields in biological research, such as immunology, metabolism, and cell biology. As a fluorescent protein, HOOK3 has high sensitivity and specificity and can be used to detect and track the expression levels of biomolecules. In addition, HOOK3 is highly scalable and can be used to study a variety of biological processes.

In summary, HOOK3 is a fluorescent protein with important biological value. By studying the function of HOOK3, scientists can better understand the molecular mechanisms in cell signal transduction, cell metabolism and cell biology processes, providing new clues for the treatment of various diseases. As a biomolecule, HOOK3 has broad application prospects in biological research.

Protein Name: Hook Microtubule Tethering Protein 3

Functions: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997)

The "HOOK3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HOOK3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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