HNRNPK: A Key Regulator of Gene Expression and DNA Replication

Target Name: HNRNPK

NCBI ID: G3190

HNRNPK

HNRNPK: A Key Regulator of Gene Expression and DNA Replication

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), also known as Isoform A, is a protein that plays a critical role in the regulation of gene expression and DNA replication in various organisms, including humans. HNRNPK is a key component of the heterochromatin complex, which is a complex of DNA, RNA, and proteins that make up the chromosomes.

HNRNPK is composed of several subunits that are held together by non-histone bonds. These subunits include a protein called K-case, which is responsible for the protein's 尾-sheet stability, as well as several other proteins that contribute to the protein's structure and function.

One of the unique features of HNRNPK is its ability to form a stable complex with DNA in the heterochromatin complex. This interaction between the protein and DNA is critical for the regulation of gene expression and DNA replication, as well as the maintenance of chromosomal stability.

HNRNPK has also been shown to play a role in the regulation of cell cycle progression, and has been linked to the development and progression of various diseases, including cancer. For example, studies have shown that high levels of HNRNPK are associated with the development of cancer, and that inhibition of the protein has been shown to be effective in inhibiting the growth of cancer cells.

In addition to its role in the regulation of cell cycle progression, HNRNPK is also known for its role in the regulation of gene expression. This is because the heterochromatin complex that HNRNPK is a part of is a highly complex and dynamic structure, and is capable of interactions with DNA and other proteins that can influence gene expression.

One of the ways that HNRNPK is involved in gene expression is through its ability to interact with specific DNA sequences. This interaction between the protein and DNA allows HNRNPK to place negative loops, or \"hangs,\" on specific DNA sequences, which can inhibit the accessibility of these sequences to transcription factors and other proteins that are involved in gene expression.

Another way that HNRNPK is involved in gene expression is through its role in the regulation of RNA polymerase (RNA-pol), a protein that is responsible for transcribing DNA information into RNA. Studies have shown that HNRNPK is able to interact with the active site of RNA-pol, and that this interaction is critical for the protein's function.

In addition to its role in the regulation of gene expression, HNRNPK is also known for its role in the regulation of DNA replication. This is because the heterochromatin complex that HNRNPK is a part of is involved in the regulation of DNA replication, and the protein is able to interact with the enzyme responsible for this process, called DNA polymerase II.

Overall, HNRNPK is a protein that plays a critical role in the regulation of gene expression, DNA replication, and cell cycle progression. Its ability to form a stable complex with DNA in the heterochromatin complex and its role in the regulation of RNA-pol and DNA polymerase II make it an attractive drug target and a potential biomarker for a variety of diseases.

Protein Name: Heterogeneous Nuclear Ribonucleoprotein K

Functions: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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