Homer1: A Scaffold Protein with Multiple Signaling Pathway Interactions

Target Name: HOMER1

NCBI ID: G9456

HOMER1

Homer1: A Scaffold Protein with Multiple Signaling Pathway Interactions

Homer1 (HOMER1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and gastrointestinal tract. It is a member of the superfamily of proteins known as scaffolds, which are involved in the formation and maintenance of tissues.

One of the unique features of Homer1 is its ability to interact with various signaling pathways, including TGF-β, NF-kappa-B, and Wnt. This makes it a promising target for the development of new drugs or biomarkers.

Homer1 functions as a scaffold protein that helps to regulate the formation of new tissues during development and also plays a role in the maintenance of tissues throughout life. It is involved in the development and maintenance of the blood vessels, which are critical for delivering oxygen and nutrients to tissues and for removing waste products.

In addition to its role in tissue development and maintenance, Homer1 is also involved in the regulation of cell signaling pathways. It has been shown to interact with various signaling pathways, including TGF-β, NF-kappa-B, and Wnt.

TGF-β is a signaling pathway that is involved in the regulation of cell growth, differentiation, and repair. It is a complex protein that consists of several conserved 尾-subunits that can be involved in various functions, including cell signaling, cell- cell interaction, and tissue formation.

Homer1 has been shown to interact with TGF-β1, which is a key member of the TGF-β family. This interaction allows Homer1 to regulate the activity of TGF-β1 and to play a role in the regulation of cell signaling pathways.

NF-kappa-B is a signaling pathway that is involved in the regulation of inflammation and immune responses. It is a large protein that consists of multiple conserved 尾-subunits that can be involved in various functions, including inflammation, DNA damage repair, and cell signaling.

Homer1 has also been shown to interact with NF-kappa-B. This interaction allows Homer1 to regulate the activity of NF-kappa-B and to play a role in the regulation of cell signaling pathways.

Wnt is a signaling pathway that is involved in the regulation of cell growth, differentiation, and development. It is a complex protein that consists of several conserved 尾-subunits that can be involved in various functions, including cell signaling, cell-cell interaction , and tissue formation.

Homer1 has been shown to interact with Wnt. This interaction allows Homer1 to regulate the activity of Wnt and to play a role in the regulation of cell signaling pathways.

In conclusion, Homer1 is a protein that is involved in the regulation of various signaling pathways, including TGF-β, NF-kappa-B, and Wnt. This makes it a promising target for the development of new drugs or biomarkers. Further research is needed to fully understand the role of Homer1 in these signaling pathways and to develop new treatments or diagnostic tools.

Protein Name: Homer Scaffold Protein 1

Functions: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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