HSD17B1: Key Enzyme for Hormone Regulation (G3292)

Target Name: HSD17B1

NCBI ID: G3292

HSD17B1

HSD17B1: Key Enzyme for Hormone Regulation

HSD17B1, a gene located on chromosome 17, is a gene that encodes a protein known as 17-beta dehydrogenase 1. This protein plays a critical role in the synthesis of a class of compounds called steroids, which are important hormones that help regulate various physiological processes in the body.

HSD17B1 is an enzyme that is responsible for the conversion of the hormone progesterone to its active form, which is called 21-hydroxylase. Progesterone is a hormone that is produced by the placenta after a pregnancy, and it plays a vital role in the development and maintenance of pregnancy. However, when progesterone is produced in the body for an extended period, it can cause various health problems, including cancer, cardiovascular disease, and obesity.

HSD17B1 is a key enzyme that helps regulate the production of progesterone from the hormone progesterone receptor alpha (PRA). PRA is a protein that is found on the surface of cancer cells, and it plays a critical role in the growth and survival of these cells. HSD17B1 helps to keep the level of PRA in the body under control by converting progesterone to its active form, which allows it to be effectively removed from the body.

In addition to its role in regulating progesterone production, HSD17B1 is also involved in the regulation of other hormones and enzymes. For example, HSD17B1 is a key enzyme in the synthesis of the hormone testosterone, which is produced by the testicles. Testosterone is important for various physiological processes in the body, including sexual function and bone growth.

HSD17B1 is also involved in the regulation of the production of androgens, which are other hormones that are produced by the body. Androgens, such as androstenedione and androsterone, play a critical role in the development and maintenance of male characteristics, including the growth of hair, the development of muscles, and the production of sex hormones.

HSD17B1 is a gene that has the potential to be a drug target or biomarker for various diseases. For example, HSD17B1 has been linked to the development of certain types of cancer, including breast and prostate cancer. Studies have also shown that HSD17B1 is involved in the regulation of various cellular processes that are associated with the development of obesity, including the production of fat cells and the inflammation that can lead to obesity.

In addition to its potential as a drug target or biomarker, HSD17B1 is also an attractive candidate for further research into the regulation of various hormones and enzymes. The synthesis of steroids and androgens is a complex process that involves the regulation of multiple hormones and enzymes, and HSD17B1 is an important enzyme that helps to keep these processes under control.

In conclusion, HSD17B1 is a critical enzyme that plays a critical role in the regulation of various hormones and enzymes in the body. Its role in the synthesis of progesterone and other hormones is important for maintaining the balance of these hormones in the body, and its involvement in the regulation of obesity and other diseases makes it an attractive candidate for further research. As research continues to advance, HSD17B1 may provide new insights into the regulation of hormones and their role in various diseases.

Protein Name: Hydroxysteroid 17-beta Dehydrogenase 1

Functions: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH

The "HSD17B1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HSD17B1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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