HSDB-7: A Potential Drug Target for Cellular Metabolism and Disease

Target Name: HSD3B7

NCBI ID: G80270

HSD3B7

HSDB-7: A Potential Drug Target for Cellular Metabolism and Disease

Human sulfate dehydrogenase B subunit-7 (HSDB-7) is a protein that plays an important biological role in the body. HSDB-7 is responsible for many important metabolic processes in cells, including cellular respiration and redox reactions. Its function and mode of action play a key role in many biological processes, and therefore it is considered a potential drug target (or biomarker).

HSDB-7 is a single-chain protein consisting of 256 amino acids. Its molecular weight is 30.9 kDa and it has a highly conserved sequence. HSDB-7 mainly catalyzes metabolic reactions in cells by binding substrates and coenzymes. It can interact with a variety of substrates and coenzymes, including CoQ, NAD+, FAD and NMN.

HSDB-7 plays multiple important roles in cellular metabolism. For example, it participates in redox reactions during cellular respiration. In aerobic respiration, HSDB-7 combines with CoQ to catalyze the redox reaction during electron transfer. In anaerobic respiration, HSDB-7 combines with NAD+ to participate in redox reactions to generate energy.

HSDB-7 is also involved in the regulation of cellular redox reactions. For example, in cells, HSDB-7 can bind to oxidoreductases, such as C oxidase, and participate in the regulation of intracellular redox reactions. In addition, HSDB-7 can also bind to other molecules, such as DNA and RNA, to participate in gene expression and regulation.

The role of HSDB-7 in disease has also been extensively studied. For example, in Parkinson's disease, variations in the HSDB-7 gene are associated with disease progression and severity. In addition, HSDB-7 is also related to a variety of neurological diseases, such as Alzheimer's disease, Parkinson's disease, and Albany syndrome.

Due to its important role in cell metabolism and disease, HSDB-7 is considered a potential drug target (or biomarker). Currently, many studies are devoted to exploring the role of HSDB-7 as a drug target or biomarker. For example, some studies are exploring the use of HSDB-7 as a treatment for Parkinson's disease.

Protein Name: Hydroxy-delta-5-steroid Dehydrogenase, 3 Beta- And Steroid Delta-isomerase 7

Functions: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells

The "HSD3B7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HSD3B7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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