HSF4_HUMAN: A Potential Drug Target and Biomarker (G3299)

Target Name: HSF4

NCBI ID: G3299

HSF4

HSF4_HUMAN: A Potential Drug Target and Biomarker

Human Solutions Foundation (HSF) is a non-profit organization dedicated to advancing the research and development of innovative solutions for various health issues, including cancer, diabetes, and neurodegenerative diseases. One of theHSF's drug targets is HSF4_HUMAN, a protein that has been identified as a potential therapeutic target for a variety of diseases.

HSF4_HUMAN is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key component of the endoplasmic reticulum, which is the network of protein transport systems that retrieves and modifies proteins before they are transported to the cell surface. The high-resolution mass spectrometry (HRMS) analysis of HSF4_HUMAN has shown that it has a molecular weight of approximately 44 kDa and a calculated pI of around 4.5.

Based on these characteristics, HSF4_HUMAN is a potential drug target for several reasons. Firstly, it is a protein that is expressed in a variety of tissues, which makes it a potential therapeutic target for a variety of diseases. Secondly, its molecular weight is small, which suggests that it is relatively easy to produce and administered orally. Finally, its calculated pI is moderate, which suggests that it has a relatively strong binding affinity for its target protein.

HSF4_HUMAN has been shown to be involved in several cellular processes that are important for various biological processes, including cell signaling, protein transport, and neurotransmission. One of the most significant findings related to HSF4_HUMAN is its role in the regulation of the blood-brain barrier (BBB), which is a critical barrier that separates the brain from the blood and ensures that only necessary nutrients and drugs can reach the brain.

Studies have shown that HSF4_HUMAN is involved in the formation and maintenance of the BBB, as well as its disruption in various diseases, such as Alzheimer's disease and Parkinson's disease. Additionally, HSF4_HUMAN has been shown to be involved in the transport of drugs across the BBB, which could be a potential mechanism for drug resistance.

Another potential mechanism for the therapeutic use of HSF4_HUMAN is its role in cancer progression. Studies have shown that HSF4_HUMAN is expressed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, HSF4_HUMAN has been shown to be involved in the regulation of cell proliferation, which could be a potential target for anti-cancer drugs.

In addition to its potential therapeutic uses, HSF4_HUMAN is also a potential biomarker for a variety of diseases. Its expression has been shown to be associated with several diseases, including Alzheimer's disease, Parkinson's disease, and cancer. Additionally, HSF4_HUMAN has been shown to be involved in the regulation of cellular processes that are important for the development and progression of these diseases.

Overall, HSF4_HUMAN is a protein that has significant potential as a drug target or biomarker. Its small molecular weight, moderate pI, and involvement in several cellular processes make it a promising target for small molecules, antibodies, or other therapeutic agents. Further research is needed to fully understand the role of HSF4_HUMAN in disease progression and the development of new therapeutic approaches.

Protein Name: Heat Shock Transcription Factor 4

Functions: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (PubMed:22587838, PubMed:23507146). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (PubMed:22587838). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (PubMed:28981088). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (By similarity)

The "HSF4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HSF4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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