Heat Shock Protein HSPA14: A Potential Drug Target for Diseases

Target Name: HSPA14

NCBI ID: G51182

HSPA14

Heat Shock Protein HSPA14: A Potential Drug Target for Diseases

Heat shock protein (HSP) family A (Hsp70) member 14 (HSPA14) is a protein that is expressed in a variety of tissues and cells, including muscle, heart, and brain. HSPA14 plays a critical role in the regulation of cellular processes that are exposed to heat stress, such as protein folding and dynamics, DNA replication, and stress responses.

HSPA14 is a member of the HSP70 family, which is a well-known protein family that is involved in the regulation of various cellular processes, including stress responses, DNA replication, and protein folding. The HSP70 family is characterized by the presence of a conserved N-terminal region that is involved in protein-protein interactions, as well as a C-terminal region that contains a variety of different domains, including a heme domain, a farnesylated cysteine residue, and a number of different secreted chaperone domains.

HSPA14 is a 14-kDa protein that is expressed in a variety of tissues and cells, including muscle, heart, and brain. It is highly conserved, with a calculated amino acid sequence of 106 amino acids that consists of 11 predicted exons. HSPA14 is also known as HSP70伪14, HSP70尾14, or HSP70纬14, based on its position within the HSP70 family.

HSPA14 is involved in a variety of cellular processes that are exposed to heat stress, including protein folding and dynamics, DNA replication, and stress responses. One of the key functions of HSPA14 is to help regulate the stability of other proteins, such as the heat shock transcription factor (HSTF) and the stress-induced chaperone (SIC) 尾.

HSPA14 is also involved in the regulation of DNA replication, as well as in the stress response. In addition, HSPA14 has been shown to play a role in the regulation of protein folding and stability, as well as in the regulation of cellular signaling pathways.

Based on these properties, HSPA14 is an attractive drug target or biomarker for a variety of diseases, including heart disease, neurodegenerative diseases, and cancer. For example, HSPA14 has been shown to be overexpressed in a variety of cancer types, and may be a useful biomarker for the diagnosis and treatment of these diseases.

In addition to its potential as a drug target or biomarker, HSPA14 also has important implications for our understanding of the regulation of cellular processes that are exposed to heat stress. The HSP70 family is involved in a wide range of cellular processes that are critical for the survival and growth of cells, and the regulation of these processes is critical for the development and maintenance of normal cellular function.

Overall, HSPA14 is a unique and important protein that is involved in a variety of cellular processes that are critical for the survival and growth of cells. As such, it is an attractive drug target or biomarker for a variety of diseases, including heart disease, neurodegenerative diseases, and cancer. Further research is needed to fully understand the role of HSPA14 in cellular processes, and to develop effective treatments for these diseases.

Protein Name: Heat Shock Protein Family A (Hsp70) Member 14

Functions: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity

The "HSPA14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HSPA14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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