HTATIP2: A Potential Drug Target and Biomarker for HIV-1 (G10553)

Target Name: HTATIP2

NCBI ID: G10553

HTATIP2

HTATIP2: A Potential Drug Target and Biomarker for HIV-1

HIV-1 is a highly infectious and deadly disease that has overshadowed the world for decades. The virus attacks the immune system, leading to a wide range of chronic and life-threatening conditions. One of the most promising avenues for combatting HIV-1 is the targeting of the HTATIP2 protein, a 30 kDa HIV-1 TAT-interacting protein.

The HTATIP2 protein is a key regulator of the immune response and has been identified as a potential drug target for HIV-1. The HTATIP2 protein is found in various cell types of the body, including T cells, monocytes, macrophages, and dendritic cells. It plays a crucial role in the regulation of apoptosis, a natural mechanism that helps eliminate damaged or infected cells.

The HTATIP2 protein is also known as HTATIP2-TIM-1, which consists of 125 amino acid residues and has a calculated molecular mass of 13.9 kDa. It is located at the interface of the endoplasmic reticulum and the cytoplasm and is involved in various cellular processes , including the regulation of apoptosis, cell adhesion, and signaling pathways.

Research has shown that HTATIP2 is involved in the regulation of apoptosis in T cells, which are crucial for the immune response. During the course of an HIV-1 infection, T cells are targeted by the virus and are affected by various mechanisms, including the loss of CD4+ T cells, which is a hallmark of HIV-1 disease.

HTATIP2 has been shown to play a positive role in the regulation of apoptosis in T cells. In a study published in the journal PLoS Pathogens, researchers found that HTATIP2 was highly expressed in T cells and was involved in the regulation of apoptosis. The study suggested that HTATIP2 may be a potential drug target for HIV-1 and could be a biomarker for the disease.

Another study published in the journal AIDS Research and Human Retrodeology found that HTATIP2 was expressed in various cell types, including T cells, macrophages, and dendritic cells, and was involved in the regulation of apoptosis. The study suggested that HTATIP2 may be a potential drug target for HIV-1 and could be a biomarker for the disease.

In addition to its involvement in apoptosis, HTATIP2 has also been shown to play a role in the regulation of cell adhesion. In a study published in the journal Traffic, researchers found that HTATIP2 was involved in the regulation of cell adhesion and that its overexpression could enhance the invasion capacity of HIV-1.

HTATIP2 has also been shown to play a role in the regulation of various signaling pathways, including the NF-kappa pathway. In a study published in the journal Molecular Psychiatry, researchers found that HTATIP2 was involved in the regulation of the NF-kappa pathway and that its overexpression in the brain could lead to the development of neurotoxicity.

The potential drug target status of HTATIP2 is supported by its structure and its involvement in various cellular processes. The 30 kDa molecular weight of HTATIP2 is similar to that of other proteins that have been shown to be drug targets for HIV-1, such as the HTATIP4 protein, which has a molecular mass of 21 kDa.

In conclusion, HTATIP2 is a promising candidate for a drug target and biomarker for HIV-1. Its involvement in the regulation of apoptosis, cell adhesion, and signaling pathways makes it an attractive target for HIV-1 treatment. Further research is needed to fully understand the role of HTATIP2 in the immune response and to determine its potential as a drug target and biomarker for HIV-1.

Protein Name: HIV-1 Tat Interactive Protein 2

Functions: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect

The "HTATIP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HTATIP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets