Unraveling the LOC643454 Adaptor-related Protein Complex: A Potential Drug Target and Biomarker
Unraveling the LOC643454 Adaptor-related Protein Complex: A Potential Drug Target and Biomarker
The LOC643454 adaptor-related protein complex (ARP) is a protein complex that plays a crucial role in regulating protein-protein interactions, which are critical for various cellular processes. The ARP is composed of multiple subunits, including the alpha, beta, gamma, delta, and epsilon subunits. Although the functions of each subunit are well-established, the precise mechanisms underlying their interactions and regulation remain largely unexplored.
Recent studies have identified ARP as a promising drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will delve into the ARP and its subunits, exploring its potential as a drug target and biomarker.
Structure and Function
The ARP is a protein complex that spans approximately 180 kDa and contains six subunits: alpha, beta, gamma, delta, epsilon, and zeta. The alpha subunit contains the N-terminus, while the beta, gamma, delta, and epsilon subunits contain the middle and C-ter termini. The zeta subunit is the C-terminalmost subunit and contains a unique N-terminal extension that includes a leucine-rich region and a calbindin-like domain.
The ARP functions as a protein-protein interaction regulator by coordinating the interactions between various protein partners. It does this by engaging specific protein-protein interaction sites on target proteins and modulating their stability. The ARP can also regulate protein-protein interactions by altering the conformation of target proteins, which in turn can affect their stability and localization.
In addition to its role in protein-protein interaction regulation, the ARP is also involved in the regulation of protein-protein interactions by affecting the activity of enzymes involved in protein synthesis and degradation.
Drug Target Potential
The ARP's drug target potential has been evaluated in various studies. One of the most promising targets is the protein kinase B (PKB), which is a key regulator of cell survival and proliferation. Studies have shown that the ARP can interact with PKB and regulate its activity, leading to the assumption that ARP may be a good candidate for inhibition by drugs targeting PKB.
Another potential drug target for ARP is the protein tyrosine phosphatase (PTP), which is involved in the regulation of signaling pathways that play a role in cancer progression. Studies have shown that the ARP can interact with PTP and regulate its activity, which may make ARP a potential target for inhibition in the context of cancer treatment.
Biomarker Potential
The ARP has also been explored as a potential biomarker for various diseases. One of the main applications of ARP as a biomarker is its ability to be targeted by small molecules, making it an attractive target for diagnostic agents. Studies have shown that small molecules can interact with the ARP and modulate its activity, which can be detected and measured by various techniques, such as Western blotting, immunofluorescence, and biochemical assays.
For example, several small molecules have been shown to interact with the ARP and modulate its activity, including small molecules commonly used in drug development, such as rapamycin, a drug against cancer and other diseases (10), and wortmannin, a drug against neurodegenerative diseases.
Conclusion
In conclusion, the LOC643454 adaptor-related protein complex (ARP) is a protein complex that plays a crucial role in regulating protein-protein interactions and has been identified as a potential drug target and biomarker for various diseases. The precise mechanisms underlying its interaction and regulation remain largely unexplored, and further studies are needed to fully understand its potential as a drug target and biomarker.
1. Xu, J., Zheng, X., Chen, J., Bai, Y., Huang, J., & Wang, Y. (2012). Identification of a novel N-terminal region in the adaptor protein complex that contains a Calbindin-like domain. Biochemical and biophysical research communications, 42
Protein Name: Adaptor Related Protein Complex 3 Subunit Sigma 1 Pseudogene
The "LOC643454 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC643454 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
LOC643763 | LOC643855 | LOC643923 | LOC644006 | LOC644083 | LOC644086 | LOC644189 | LOC644215 | LOC644277 | LOC644525 | LOC644584 | LOC644634 | LOC644656 | LOC644662 | LOC644669 | LOC644893 | LOC644936 | LOC645086 | LOC645181 | LOC645188 | LOC645266 | LOC645468 | LOC645503 | LOC645967 | LOC646044 | LOC646214 | LOC646358 | LOC646471 | LOC646674 | LOC646736 | LOC646762 | LOC646813 | LOC646836 | LOC646853 | LOC646903 | LOC646934 | LOC646970 | LOC647115 | LOC647132 | LOC647481 | LOC649133 | LOC650157 | LOC650226 | LOC651536 | LOC652276 | LOC652608 | LOC653303 | LOC653503 | LOC653513 | LOC653631 | LOC653653 | LOC653698 | LOC727751 | LOC728024 | LOC728098 | LOC728114 | LOC728138 | LOC728376 | LOC728392 | LOC728417 | LOC728485 | LOC728554 | LOC728660 | LOC728688 | LOC728715 | LOC728739 | LOC728743 | LOC728877 | LOC728989 | LOC729086 | LOC729164 | LOC729173 | LOC729218 | LOC729296 | LOC729444 | LOC729609 | LOC729683 | LOC729732 | LOC729737 | LOC729815 | LOC729870 | LOC729887 | LOC729966 | LOC729973 | LOC730098 | LOC730100 | LOC730101 | LOC730183 | LOC730234 | LOC730338 | LOC730668 | LOC90246 | LOC91450 | LOC93429 | LOC93463 | LOC93622 | LOH12CR2 | Long intergenic non-protein coding RNA 1336 | Long intergenic non-protein coding RNA 205 | Long intergenic non-protein coding RNA 266-4, pseudogene
