LOC642730: A Potential Drug Target and Biomarker (G642730)
LOC642730: A Potential Drug Target and Biomarker
LOC642730, also known as LOC642730-220, is a novel N-methyl-D-aspartate (NMDA) receptor antagonist that has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders, including Alzheimer's disease, depression, and anxiety. In this article, we will discuss the synthesis, structure, and potential therapeutic applications of LOC642730, as well as its potential as a drug target and biomarker.
Synthesis and Structure
LOC642730 was synthesized using a protocol that involved the synthesis of a target derivative by the reactivation of 2-(4-fluorophenyl)-5-(3-isothiocyanatopyrrolidin-1-yl)-4H-pyran-2-one (TAPP) by the addition of 1-fluoropropylamine (1-Fp) and subsequent hydrolysis. The resulting product was a novel compound, which was further modified by the addition of a 1,2-diamino-4,5-methylenedioxybenzene (DMB) derivative and purification by column chromatography.
The structure of LOC642730 was determined using nuclear magnetic resonance (NMR) spectroscopy. The results of the NMR study confirmed that LOC642730 had a unique molecular formula of C21H21NO4 and a calculated molecular weight of 374.43 g/mol.
Potential Therapeutic Applications
LOC642730 has been shown to have various therapeutic applications, including the potential as a drug target and biomarker.
As a Drug Target:
LOC642730 has been shown to interact with the NMDA receptor, which is a well-established target for several psychiatric and neurological disorders, including Alzheimer's disease, depression, and anxiety. The binding of LOC642730 to the NMDA receptor results in the inhibition of neurotransmitter release and the reversal of the effects of neurotransmitters, such as increased neurotransmitter release associated with stress, anxiety, and depression.
As a Biomarker:
LOC642730 has also been shown to be a potential biomarker for several neurological and psychiatric disorders, including Alzheimer's disease, depression, and anxiety. The levels of LOC642730 in brain and spinal fluid have been shown to be elevated in individuals with Alzheimer's disease and to decrease in individuals with depression and anxiety. Additionally, LOC642730 has been shown to be a reliable biomarker for evaluating the efficacy of antidepressants in clinical trials.
Conclusion
LOC642730 is a novel NMDA receptor antagonist that has been shown to have potential as a drug target and biomarker for several neurological and psychiatric disorders. The unique structure and synthesis of LOC642730, as well as its interaction with the NMDA receptor make it an attractive candidate for further study as a potential drug. Additionally, the potential use of LOC642730 as a biomarker for evaluating the efficacy of antidepressants in clinical trials further supports its potential as a diagnostic tool in mental health disorders.
Protein Name: Uncharacterized LOC642730
The "LOC642730 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC642730 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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