TNFSF12-TNFSF13: A Potential Drug Target for Cell Death and Inflammation

Target Name: TNFSF12-TNFSF13

NCBI ID: G407977

TNFSF12-TNFSF13

TNFSF12-TNFSF13: A Potential Drug Target for Cell Death and Inflammation

TNFSF12-TNFSF13, also known as tumor necrosis factor (ligand) superfamily member 12-member 13, is a protein that plays a crucial role in various cellular processes in the body. It is a member of the TNFSF family, which is known for its ability to induce cell death, repair, and inflammation. The TNFSF12-TNFSF13 protein is expressed in various tissues and cells throughout the body, including the immune system, and has been implicated in a number of diseases, including cancer. As a result, it is a potential drug target or biomarker for a variety of therapeutic approaches.

The TNFSF12-TNFSF13 protein is composed of 118 amino acid residues and has a calculated molecular mass of 13.9 kDa. It is characterized by a long extracellular domain that includes a region of 11 amino acids known as the N-terminal hypervariable region (HVR1), as well as a variable region that includes several conserved amino acids known as HVR2-HVR7. The variable region includes a unique feature known as a variable region in the middle of the protein, which is composed of four conserved amino acids that are involved in the formation of a distinct alpha-helices.

The TNFSF12-TNFSF13 protein is involved in a variety of cellular processes, including inflammation, cell adhesion, and signaling. One of its most well-known functions is its role in the regulation of cell death. When cells are exposed to TNFSF12-TNFSF13, the protein can induce cell death through a variety of mechanisms, including the production of reactive oxygen species (ROS) and the formation of autophagy. This is thought to be an important mechanism by which TNFSF12-TNFSF13 contributes to tumor development and progression.

In addition to its role in cell death, TNFSF12-TNFSF13 is also involved in the regulation of cell adhesion. The protein is known to play a role in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and prevent the excessive migration of cells. TNFSF12-TNFSF13 is also involved in the regulation of cell-cell adhesion through its ability to interact with the protein known as cadherin, which is a major adhesion molecule.

Another function of TNFSF12-TNFSF13 is its role in cell signaling. The protein is involved in a variety of signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. These pathways are involved in the regulation of cellular processes such as cell growth, differentiation, and inflammation. TNFSF12-TNFSF13 is thought to play a role in the regulation of these processes by its ability to interact with the protein known as transforming growth factor (TGF-β1).

TNFSF12-TNFSF13 is also involved in the regulation of inflammation. The protein is known to play a role in the regulation of immune responses, including the regulation of T cell proliferation and the production of antibodies. In addition, TNFSF12-TNFSF13 is thought to contribute to the regulation of inflammation through its ability to interact with the protein known as nuclear factor kappa B (NFKB).

Due to its involvement in a variety of cellular processes, TNFSF12-TNFSF13 is a potential drug target or biomarker for a variety of therapeutic approaches. For example, because the protein is involved in the regulation of cell death, it may be a good candidate for drugs that are designed to

Protein Name: TNFSF12-TNFSF13 Readthrough

Functions: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion

The "TNFSF12-TNFSF13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TNFSF12-TNFSF13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets