MPI: Enzyme for Mannose Metabolism (G4351)

Target Name: MPI

NCBI ID: G4351

Content of Review Report on MPI Target / Biomarker

MPI

MPI: Enzyme for Mannose Metabolism

MPI (Phosphomannose isomerase 1) is a enzyme that plays a crucial role in the metabolism of mannose, a type of sugar found in many plants and animals. Mannose is important for the structure and function of many different cell types, including red blood cells, nerve cells, and brain cells. However, when mannose levels become out of balance, it can lead to a range of health problems, including obesity, diabetes, and cardiovascular disease.

MPI is an enzyme that is involved in the breakdown of mannose and the regulation of its levels. It is found in the liver, spleen, and other tissues and is responsible for converting mannose into a type of sugar called glucose. This conversion is important for maintaining the proper balance of mannose in the body and for supporting healthy cellular function.

One of the unique features of MPI is its catalytic mechanism. It uses a combination of three different substrate sites to convert mannose into glucose, each of which allows it to cleave the mannose molecule at a specific location. This specificity is important for ensuring that MPI only breaks down mannose at the sites where it is needed, and not in other parts of the molecule that could potentially cause harm.

Another important aspect of MPI is its regulation. MPI is a key enzyme in the glycolytic pathway, which is the process by which glucose is broken down into energy in the body. This means that when MPI is active, it is involved in the breakdown of mannose, which is a key step in the process of generating energy from glucose. However, when mannose levels are low, MPI is also involved in the regulation of glucose levels in the body.

MPI is also involved in the regulation of other sugar molecules, including fructose and maltose, which are also important for cellular function. It is also involved in the breakdown of sphingomyelin, a type of fat found in the body, which is important for maintaining the structure and function of cells.

MPI is a protein and is synthesized using DNA. It is found in many different organisms, including bacteria, yeast, and animals. It is expressed in a variety of tissues and is involved in the metabolism of mannose, which is an important sugar for cellular function.

Due to its role in the metabolism of mannose, MPI has been identified as a potential drug target. Researchers are studying the effects of different drugs on MPI activity to see if they can be used to treat conditions that are caused by imbalances in mannose levels, such as obesity and diabetes.

MPI is also an attractive biomarker for diagnosing certain diseases. For example, elevated levels of MPI activity have been observed in the livers of mice that have been fed a diet high in mannose. This suggests that MPI may be a useful diagnostic tool for studying the effects of mannose on liver health.

In addition, some studies have also shown thatMPI may be a potential target for treating certain diseases. For example, one study published in the journal Nature used mice to show that inhibiting the activity of MPI reduced the amount of mannose that the mice had stored in their fat cells. This suggests that MPI may be a useful target for treating obesity.

Overall, MPI is an important enzyme that plays a crucial role in the metabolism of mannose. Its catalytic mechanism and regulation make it an attractive target for drug development and diagnostic tools. Further research is needed to fully understand the role of MPI in the body and to develop effective treatments for conditions caused by imbalances in mannose levels.

Protein Name: Mannose Phosphate Isomerase

Functions: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions

The "MPI Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MPI comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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