OR4M1: A GPCR Molecule Involved in The Sense of Smell and Neurological Disorders
OR4M1: A GPCR Molecule Involved in The Sense of Smell and Neurological Disorders
OR4M1 (Olfactory Receptor Family 4 Subfamily M Member 1) is a G protein-coupled receptor (GPCR) that is expressed in the olfactory system of the human nose. It plays a crucial role in the sense of smell and is responsible for the detection of odors. OR4M1 is a transmembrane protein that is characterized by a long extracellular portion and a short intracellular portion. The intracellular portion of OR4M1 contains a catalytic alpha-heme that is involved in the GPCR signaling process.
OR4M1 is a member of the Olfactory Receptor Family 4 (OR4), which is a subfamily of GPCRs that are involved in the sense of smell. The OR4 subfamily includes four GPCRs: OR4M1, OR4M2, OR4M3, and OR4M4. OR4M1 is the most well-studied member of the OR4 subfamily and is responsible for the majority of the sensory responses associated with the sense of smell.
OR4M1 is expressed in the olfactory system of the human nose and is involved in the detection of a wide range of odors, including scents such as soap, lotion, and perfumes. It is also involved in the perception of taste, but this function is not well understood.
The intracellular portion of OR4M1 contains a catalytic alpha-heme that is involved in the GPCR signaling process. This alpha-heme is a critical structural element that allows OR4M1 to interact with GPCRs that are located in the cytoplasm. The catalytic alpha-heme is involved in the formation of a covalent complex with the GPCR, which triggers the downstream signaling cascade.
OR4M1 has been shown to play a role in the development and progression of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and migraine. It is also involved in the regulation of pain and anxiety.
In addition to its involvement in neurological disorders, OR4M1 is also a potential drug target. Researchers have identified several small molecules that can interact with the catalytic alpha-heme of OR4M1 and have shown that these molecules can inhibit the activity of OR4M1. These molecules have the potential to be used as drugs for the treatment of neurological disorders.
OR4M1 is also a potential biomarker for various neurological disorders. The loss of OR4M1 has been observed in the brains of individuals with Alzheimer's disease, and these individuals have been shown to have reduced levels of scents in their nostrils. Similarly, individuals with Parkinson's disease have been shown to have reduced levels of scents in their nostrils.
In conclusion, OR4M1 is a GPCR that is involved in the sense of smell and plays a crucial role in the development and progression of various neurological disorders. Its catalytic alpha-heme is involved in the GPCR signaling process and has been shown to play a role in the regulation of neurological disorders. OR4M1 is also a potential drug target and biomarker for these disorders. Further research is needed to fully understand the role of OR4M1 in the sense of smell and its potential as a drug and biomarker.
Protein Name: Olfactory Receptor Family 4 Subfamily M Member 1
Functions: Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release (PubMed:31230984). Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity (By similarity). In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP (By similarity)
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More Common Targets
OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5 | OR4P4 | OR4Q3 | OR4S1 | OR4S2 | OR4T1P | OR4V1P | OR4X1 | OR4X2 | OR51A1P | OR51A2 | OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5 | OR52B2 | OR52B4 | OR52B6 | OR52D1 | OR52E1 | OR52E2 | OR52E4 | OR52E5 | OR52E6 | OR52E8 | OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1 | OR52N4 | OR52N5 | OR52R1 | OR52W1 | OR52Z1P | OR56A1 | OR56A3 | OR56A4 | OR56A5 | OR56B1 | OR56B4 | OR5A1 | OR5A2 | OR5AC1 | OR5AC2 | OR5AK2 | OR5AK4P | OR5AN1 | OR5AP2 | OR5AR1 | OR5AS1 | OR5AU1 | OR5B12 | OR5B17 | OR5B2 | OR5B21 | OR5B3 | OR5BA1P | OR5C1 | OR5D13 | OR5D14 | OR5D16 | OR5D17P | OR5D18 | OR5E1P
