Target Name: MUC2
NCBI ID: G4583
Review Report on MUC2 Target / Biomarker Content of Review Report on MUC2 Target / Biomarker
MUC2
Other Name(s): mucin 2, oligomeric mucus/gel-forming | Intestinal mucin-2 | mucin 2, intestinal/tracheal | Mucin 2, oligomeric mucus/gel-forming | Mucin-2 precursor | MUC2_HUMAN | MLP | Mucin-2 | SMUC | MUC-2

MUC2: Potential Drug Target and Regulator of Tissue and Organ Development

MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) is a protein that is expressed in various body tissues and is known for its role in the production and maintenance of mucous membranes, which line the surfaces of various body organs and glands. MUC2 is a glycoprotein that consists of a single transmembrane domain and a cytoplasmic tail. It is one of the most abundant proteins in the human body, and its levels are highly regulated in response to various environmental and biological factors.

MUC2 has been identified as a potential drug target and has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its functions include cell adhesion, migration, and invasion, as well as regulation of the extracellular matrix (ECM) and the immune response. MUC2 has also been shown to be involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of MUC2 is its role in the production and maintenance of mucous membranes. Mucous membranes are specialized epithelial cells that line the surfaces of various body organs and glands, and they play a crucial role in protecting the body against harmful substances and Maintaining a healthy balance of fluids within the body. MUC2 is involved in the production and maintenance of these membranes, as well as the regulation of their structure and function.

MUC2 is also involved in several other cellular processes that are important for the development and maintenance of tissues and organs. For example, MUC2 has been shown to be involved in cell adhesion and migration, which are critical processes that are necessary for the growth and development of tissues and organs. MUC2 has also been shown to be involved in the regulation of the ECM, which is the complex of molecules that surround and support cells in the body. This includes the regulation of extracellular matrix (extracellular matrix), which is the extracellular matrix that surrounds and supports cells.

In addition to its role in the production and maintenance of mucous membranes and the regulation of the ECM, MUC2 is also involved in several other cellular processes that are important for the development and maintenance of tissues and organs. For example, MUC2 has been shown to be involved in the regulation of cell signaling pathways, which are the processes by which cells communicate with one another and coordinate their activities. This includes the regulation of angiogenesis, which is the process by which new blood vessels are formed to supply oxygen and nutrients to tissues and organs.

MUC2 is also involved in the regulation of the immune response, which is the process by which the body defends itself against foreign substances and pathogens. This includes the regulation of the activation and regulation of natural killer cells, which are a critical part of the immune system. MUC2 has also been shown to be involved in the regulation of inflammation, which is a critical part of the immune response.

In conclusion, MUC2 is a protein that is involved in a variety of cellular processes that are important for the development and maintenance of tissues and organs. Its functions include cell adhesion, migration, and invasion, as well as regulation of the ECM, angiogenesis, and the immune response. MUC2 has also been identified as a potential drug target and has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of MUC2 in these diseases and to develop effective treatments.

Protein Name: Mucin 2, Oligomeric Mucus/gel-forming

Functions: Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:17058067, PubMed:19432394, PubMed:33031746). Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine (PubMed:19432394, PubMed:33031746). MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange (PubMed:33031746, PubMed:36206754). Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells (PubMed:36206754). Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site (PubMed:36206754). MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells (PubMed:36206754). Mucin gels store antimicrobial molecules that participate in innate immunity (PubMed:33031746). Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (PubMed:33031746). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (By similarity). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (By similarity)

The "MUC2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MUC2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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