NGFR: Role in Cell Signaling, Angiogenesis and Immune Response

Target Name: NGFR

NCBI ID: G4804

NGFR

NGFR: Role in Cell Signaling, Angiogenesis and Immune Response

NGFR (CD271) is a protein that is expressed in various tissues throughout the body, including the skin, heart, liver, and kidneys. It is a member of the transforming growth factor receptor (TGFR) family, which is a group of transmembrane proteins that play a critical role in cell growth, differentiation, and survival.

NGFR is involved in many different processes in the body, including cell signaling, angiogenesis, and immune responses. It has been shown to play a key role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the main functions of NGFR is its role in cell signaling. NGFR is a tyrosine receptor, which means that it can interact with other proteins that contain tyrosine residues. When NGFR is activated, it forms a complex with a protein called FGF-1, which is a key regulator of cell growth and differentiation. This interaction between NGFR and FGF-1 helps to control the growth and proliferation of cells.

NGFR is also involved in the process of angiogenesis, which is the formation of new blood vessels. During angiogenesis, NGFR plays a key role in the regulation of blood vessel growth and differentiation. It has been shown to promote the formation of new blood vessels in various tissues, including the skin and the placenta.

NGFR is also involved in the immune response. It has been shown to play a key role in the regulation of T cell development and function. NGFR has been shown to interact with the protein PD-L1, which is a negative regulator of T cell proliferation. This interaction between NGFR and PD-L1 helps to control the regulation of T cell growth and function.

NGFR has also been shown to be a potential drug target in various diseases. For example, NGFR has been shown to be involved in the development and progression of various types of cancer, including breast cancer and colorectal cancer. It has also been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

NGFR has also been shown to be involved in the regulation of inflammation. It has been shown to play a key role in the regulation of immune responses and inflammation. NGFR has been shown to interact with various proteins that are involved in inflammation, including NF-kappa-B and MAPK. This interaction between NGFR and these proteins helps to regulate the immune response and the regulation of inflammation.

NGFR is also involved in the regulation of cell adhesion. It has been shown to play a key role in the regulation of cell-cell adhesion, which is the interaction between cells that results in the formation of tight junctions and adherens junctions. NGFR has been shown to interact with various proteins that are involved in cell-cell adhesion, including cadherins and tight junctions.

NGFR has also been shown to play a key role in the regulation of cell survival. It has been shown to play a key role in the regulation of cell survival by promoting the production of various signaling molecules that can help to prevent cell death. NGFR has been shown to interact with various proteins that are involved in cell survival, including Bcl-2 and p53. This interaction between NGFR and these proteins helps to regulate cell survival.

NGFR is also involved in the regulation of DNA replication. It has been shown to play a key role in the regulation of DNA replication, which is the process by which a cell replicates its DNA. NGFR has been shown to interact with various proteins that are involved in DNA replication, including Rb and p53. This interaction between NGFR and these proteins helps to regulate DNA replication.

NGFR is also involved in the regulation of cell migration. It has been shown to play

Protein Name: Nerve Growth Factor Receptor

Functions: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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