CPSF3 Subunit: Potential Drug Target Or Biomarker (G51692)

Target Name: CPSF3

NCBI ID: G51692

CPSF3

Other Name(s): CPSF 73 kDa subunit | Cleavage and polyadenylation specificity factor subunit 3 (isoform a) | cleavage and polyadenylation specific factor 3, 73kDa | cleavage and polyadenylation specific factor 3 | C

CPSF3 Subunit: Potential Drug Target Or Biomarker

The CPSF3 subunit is a protein that is expressed in the brain and is known for its role in the regulation of synaptic plasticity. Synaptic plasticity is the ability of the brain to change and adapt over time, and it is a critical factor in the development and maintenance of neural circuits. The CPSF3 subunit has been shown to play a crucial role in the regulation of synaptic plasticity, and as a result, it has potential as a drug target or biomarker.

The CPSF3 subunit is a member of the CPSF family, which includes a variety of proteins that are involved in the regulation of synaptic plasticity. These proteins are known as CPSFases because they contain a protein domain that is similar to the enzyme active site, which is the region of the protein that catalyzes chemical reactions. The CPSF3 subunit is a 73 kDa protein, which means that it has a molecular weight of approximately 73,000 daltons.

The CPSF3 subunit is expressed in the brain and is involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. Synaptic plasticity is critical for the development and maintenance of neural circuits, and it is involved in a wide range of cognitive functions, including learning, memory, and attention. The CPSF3 subunit is shown to play a crucial role in the regulation of synaptic plasticity, and as a result, it has potential as a drug target or biomarker.

One of the key functions of the CPSF3 subunit is its role in the regulation of the strengthening of synaptic connections, which is the process by which new connections are formed between neurons in the brain. The CPSF3 subunit is shown to play a crucial role in the Regulation of synaptic strength, by affecting the levels of a protein called Baijiaxin, which is involved in the strengthening of synaptic connections.

In addition to its role in the regulation of synaptic plasticity, the CPSF3 subunit is also involved in the regulation of synaptic homeostasis, which is the stability of the chemical and physical properties of the synapse. The CPSF3 subunit is shown to play a crucial role in the regulation of synaptic homeostasis, by affecting the levels of a protein called VEB, which is involved in the stability of the synapse.

The CPSF3 subunit is also involved in the regulation of synaptic plasticity in response to changes in the environment. For example, when the CPSF3 subunit is activated, it is shown to increase the levels of synaptic, which is involved in the strengthening of synaptic connections, and to decrease the levels of VEB, which is involved in the stability of the synapse. This increase in Baijiaxin and decrease in VEB is thought to promote synaptic plasticity by allowing the brain to adapt to changes in the environment.

In conclusion, the CPSF3 subunit is a protein that is expressed in the brain and is involved in the regulation of synaptic plasticity. Synaptic plasticity is critical for the development and maintenance of neural circuits, and the CPSF3 subunit is shown to play a crucial role in the regulation of synaptic plasticity. As a result, the CPSF3 subunit has potential as a drug target or biomarker. Further research is needed to fully understand the role of the CPSF3 subunit in synaptic plasticity and its potential as a drug target or biomarker.

Protein Name: Cleavage And Polyadenylation Specific Factor 3

Functions: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)

The "CPSF3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPSF3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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