ATR: A Drug Target / Disease Biomarker (G545)

Target Name: ATR

NCBI ID: G545

Content of Review Report on ATR Target / Biomarker

ATR

ATR: A Drug Target / Disease Biomarker

ATR (apoptosis-triggered receptor) is a protein that is expressed in many different tissues throughout the body. It is involved in the process of apoptosis, which is a natural response of cells to environmental stressors such as DNA damage, infection, or exposure to toxins. ATR is also involved in the regulation of cell survival and proliferation, and is thought to play a key role in the development and progression of many diseases. As a result, ATR has been identified as a potential drug target and is the focus of ongoing research in the field of pharmacology.

The protein encoded by the AT gene is a member of the tyrosine kinase family, and is composed of 219 amino acid residues. It has a molecular weight of 23.5 kDa and a pI of 2.8. ATR is primarily expressed in skeletal muscles, heart, liver, and brain, and is also found in various other tissues and organs. It is a potent inhibitor of cell proliferation, and has been shown to induce apoptosis in a variety of cell types.

ATR is involved in the regulation of many different cellular processes, including cell survival, proliferation, and apoptosis. It is thought to play a key role in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. It is also involved in the regulation of pain perception and the development of neuropathic pain.

One of the key functions of ATR is its role in apoptosis. Apoptosis is a natural response of cells to environmental stressors, and is characterized by the release of cellular debris and the programmed cell death that follows. ATR is involved in the regulation of apoptosis, and is thought to play a key role in the execution of this process.

ATR is also involved in the regulation of cell survival and proliferation. It is a potent inhibitor of cell proliferation, and has been shown to induce cell cycle arrest and apoptosis in a variety of cell types. This may have important implications for the development of cancer, as increased cell proliferation is a key hallmark of this disease.

In addition to its role in apoptosis and cell survival, ATR is also involved in the regulation of pain perception and the development of neuropathic pain. It is thought to play a key role in the development of neuropathic pain, and is involved in the regulation of pain sensitivity.

The potential drug target status of ATR is due to its involvement in the regulation of many different cellular processes, including apoptosis, cell survival, and pain perception. As a result, ATR is an attractive target for the development of new pharmaceuticals for the treatment of a wide range of diseases.

In conclusion, ATR is a protein that is expressed in many different tissues throughout the body and is involved in the regulation of apoptosis, cell survival, and pain perception. Its potential as a drug target makes it an attractive target for the development of new pharmaceuticals for the treatment of a wide range of diseases. Further research is needed to fully understand the role of ATR in the development and progression of disease, and to develop effective treatments based on this protein.

Protein Name: ATR Serine/threonine Kinase

Functions: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity)

The "ATR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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