LAPTM4B: Potential Drug Target Or Biomarker (G55353)

Target Name: LAPTM4B

NCBI ID: G55353

LAPTM4B

LAPTM4B: Potential Drug Target Or Biomarker

LAPTM4B, also known as Lysosome-associated transmembrane protein 4-beta, is a protein that is expressed in various cell types, including neurons, astrocytes, and pericytes. It is a member of the LAPTM4 family, which is characterized by the presence of a unique transmembrane domain and a cytoplasmic tail.

The LAPTM4B protein is involved in a variety of cellular processes, including the regulation of cell signaling pathways, the maintenance of cellular structure and homeostasis, and the contribution to the development and maintenance of neural networks.

One of the most significant functions of LAPTM4B is its role in the regulation of the vesicle system, which is a critical aspect of intracellular transportation and communication. LAPTM4B is involved in the formation and maintenance of vesicles, as well as the regulation of the trafficking of vesicular particles to and from the plasma membrane.

In addition to its role in vesicle regulation, LAPTM4B is also involved in the regulation of cellular signaling pathways. It has been shown to be involved in the regulation of several signaling pathways, including the TGF-beta pathway, the Wnt pathway, and the Hedgehog pathway.

LAPTM4B is also involved in the regulation of cellular homeostasis, including the regulation of ion homeostasis and the maintenance of aqueous and osmotic homeostasis. It plays a critical role in the regulation of the osmotic stress response, which is a critical aspect of the regulation of cellular homeostasis.

In addition to its role in cellular signaling pathways and homeostasis, LAPTM4B is also involved in the development and maintenance of neural networks. It has been shown to be involved in the regulation of synaptic plasticity, which is the ability of neural networks to change and adapt in response to experience.

Given its involvement in a variety of cellular processes, LAPTM4B is a potential drug target or biomarker. Studies have shown that LAPTM4B is highly expressed in several types of cancer, including breast, ovarian, and colorectal cancer. Additionally, several studies have shown that LAPTM4B is involved in the regulation of cellular signaling pathways, including the TGF-beta pathway, the Wnt pathway, and the Hedgehog pathway.

Furthermore, LAPTM4B has been shown to be involved in the regulation of cellular homeostasis, including the regulation of ion homeostasis and the maintenance of aqueous and osmotic homeostasis. It plays a critical role in the regulation of the osmotic stress response, which is a critical aspect of the regulation of cellular homeostasis.

In addition to its role in cellular signaling pathways and homeostasis, LAPTM4B is also involved in the development and maintenance of neural networks. It has been shown to be involved in the regulation of synaptic plasticity, which is the ability of neural networks to change and adapt in response to experience.

Overall, LAPTM4B is a protein that is involved in a variety of cellular processes, including the regulation of cell signaling pathways, the maintenance of cellular structure and homeostasis, and the development and maintenance of neural networks. Its involvement in these processes makes it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of LAPTM4B in cellular processes and its potential as a drug target or biomarker.

Protein Name: Lysosomal Protein Transmembrane 4 Beta

Functions: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656)

The "LAPTM4B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LAPTM4B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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