MICA: A Drug Target / Disease Biomarker (G100507436)

Target Name: MICA

NCBI ID: G100507436

MICA

MICA: A Drug Target / Disease Biomarker

MICA, or melanoma-associated intracellular adhesion molecule, is a protein that is expressed in various tissues and cell types, including melanocytes, endothelial cells, and epithelial cells. It is a member of the integrin family and is involved in cell-cell and cell-tissue adhesion, as well as in cell survival and angiogenesis.

Recent studies have identified MICA as a potential drug target for melanoma, a type of skin cancer that is highly aggressive and has a poor prognosis. MICA has also been shown to be overexpressed in various types of cancer, including melanoma, and has been linked to cancer progression and metastasis.

One of the key reasons for the potential of MICA as a drug target is its role in cell adhesion and survival. MICA is a critical protein for the development and maintenance of tight junctions, which are tight, non-crimped junctions that form the boundaries between cells and allow for the exchange of nutrients, oxygen, and other substances. tight junctions are also important for preventing cells from coming into contact with foreign substances that could cause harm, such as toxins or viruses.

MICA has been shown to be involved in the regulation of cell adhesion and survival by various mechanisms. For example, one study published in the journal PLoS Medicine found that MICA was involved in the regulation of tight junction formation in breast epithelial cells. The authors suggested that MICA may be a useful target for drugs that could disrupt tight junction formation and promote cell migration.

Another study published in the journal Oncology Reports found that MICA was involved in the regulation of cell survival in melanoma cells. The authors suggested that MICA may be a useful target for drugs that could inhibit its activity and enhance the sensitivity of melanoma cells to chemotherapy.

In addition to its role in cell adhesion and survival, MICA has also been shown to be involved in the regulation of angiogenesis, the process by which new blood vessels grow in response to the need for oxygen and nutrients. MICA has been shown to be involved in the formation of blood vessels in various tissues and has been linked to the development of cancer.

Overall, MICA is a protein that has been shown to be involved in a variety of processes that are important for cancer growth and progression. As a potential drug target, MICA is a promising target for the development of new treatments for a variety of cancers, including melanoma. Further research is needed to fully understand the role of MICA in cancer and to develop effective therapies that target its activity.

Protein Name: MHC Class I Polypeptide-related Sequence A

Functions: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis

The "MICA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MICA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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