INPP5E-V1: A Versatile Molecule for Drug Screening and Therapeutic Research

Target Name: INPP5E

NCBI ID: G56623

INPP5E

INPP5E-V1: A Versatile Molecule for Drug Screening and Therapeutic Research

INPP5E (INPPT) can play a role in multiple biomolecules and cellular functions, such as signal transduction, cell proliferation, apoptosis, and neuronal connection. INPP5E is a transcription factor that mainly acts in the G1 phase and S phase of the cell cycle. phase. In the G1 phase, INPP5E promotes the initiation of RNA polymerase by binding to specific sequences on DNA, thereby participating in gene expression. In S phase, INPP5E inhibits the activity of RNA polymerase by binding to specific sequences on DNA, thereby participating in gene expression. DNA replication and cell cycle progression.

A variant of INPP5E, INPP5E variant 1 (INPP5E-V1), is a genetic mutation that occurs in humans and other animals. This variant not only produces interesting functional changes in biology, but also has potential application value in drug screening and treatment.

drug screening

Variants of INPP5E-V1 have broad applications in drug screening. Because INPP5E-V1 has a unique mechanism of action in drug screening, it is widely used in drug screening and drug target research. For example, using the high efficiency and selectivity of INPP5E-V1, researchers can quickly test new drug molecules and determine whether they are pharmacologically active. In addition, INPP5E-V1 can also be used for drug target research. By expressing INPP5E-V1 in cells and using specific antibodies to detect specific proteins in the cells, researchers can determine whether drug molecules interact with these proteins and thus determine the pharmacological activity of the drug molecules.

Biomarkers

INPP5E-V1 can also be used for biomarker research. Since INPP5E-V1 plays an important role in the cell cycle, it can be used as a biomarker of cell cycle activity. By expressing INPP5E-V1 in cells and using specific antibodies to detect specific proteins in cells, researchers can determine whether the cell cycle is in a specific state, and thus determine the state of cell cycle activity. These biomarkers can be used to evaluate the effects of drugs on the cell cycle and provide an important theoretical basis for drug research.

treat

Due to its important role in drug screening and biomarker research, INPP5E-V1 is also widely used in therapeutic research. For example, using the high efficiency and selectivity of INPP5E-V1, researchers can quickly test new drug molecules and determine whether they are pharmacologically active. In addition, INPP5E-V1 can also be used in therapeutic research. By expressing INPP5E-V1 in cells and using specific antibodies to detect specific proteins in the cells, researchers can determine whether drug molecules interact with these proteins and thus determine the pharmacological activity of the drug molecules. These drug molecules can be used to treat various diseases, such as cancer, neurodegenerative diseases, etc.

Protein Name: Inositol Polyphosphate-5-phosphatase E

Functions: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity)

The "INPP5E Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INPP5E comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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