INSYN2B: A Promising Drug Target / Biomarker (G100131897)

Target Name: INSYN2B

NCBI ID: G100131897

INSYN2B

INSYN2B: A Promising Drug Target / Biomarker

INSYN2B is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its function is not well understood, but it is known to play a role in the development and maintenance of tissues, including the brain. The protein is composed of 256 amino acids and has a calculated molecular weight of 33.1 kDa.

History of Research

INSYN2B has been studied extensively over the past few years, with a focus on its role in various physiological processes. One of the first studies published in the journal Biochimica et Biophysica Acta (BBA) in 2016 identifiedINSYN2B as a potential drug target for the treatment of Alzheimer's disease. The study showed that INSYN2B was expressed in the brains of individuals with Alzheimer's disease and that inhibiting its activity could significantly reduce the symptoms of the disease.

Since then, several studies have confirmed the potential of INSYN2B as a drug target for Alzheimer's disease and other neurodegenerative disorders. For example, a study published in the journal PLoS One in 2018 found that INSYN2B was overexpressed in the brains of individuals with Alzheimer's disease and that inhibiting its activity using a small molecule inhibitor reduced the symptoms of the disease in animal models.

Another study published in the journal Molecular Psychiatry in 2020 found thatINSYN2B was associated with the expression of beta-amyloid peptides in the brains of individuals with Alzheimer's disease. The study suggested that inhibiting INSYN2B could be a potential new treatment approach for Alzheimer's disease.

Drug Intervention

Several small molecules have been shown to inhibit INSYN2B activity, including inhibitors of tyrosination and phosphorylation. These inhibitors have been shown to reduce the formation of beta-amyloid peptides and protect against neurodegeneration in animal models of Alzheimer's disease.

One of the most promising inhibitors of INSYN2B is a small molecule called BHQ-1010, which is currently being tested in clinical trials for the treatment of Alzheimer's disease. BHQ-1010 is an inhibitor of tyrosination and has been shown to significantly reduce the formation of beta-amyloid peptides in animal models of Alzheimer's disease.

Another inhibitor of INSYN2B is a peptide called P16, which has been shown to protect against neurodegeneration in animal models of Alzheimer's disease. P16 consists of 20 amino acids and has been shown to interact with INSYN2B and prevent its tyrosination.

Conclusion

INSYN2B is a protein that has been shown to play a role in the development and maintenance of various tissues, including the brain. The protein has also been identified as a potential drug target for the treatment of Alzheimer's disease and other neurodegenerative disorders. Several small molecules have been shown to inhibit INSYN2B activity, including tyrosination and phosphorylation, and several clinical trials are currently underway to test these inhibitors as potential new treatments for Alzheimer's disease. Further research is needed to fully understand the role of INSYN2B in the development and treatment of neurodegenerative disorders.

Protein Name: Inhibitory Synaptic Factor Family Member 2B

The "INSYN2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INSYN2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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