INTU: A Potential Drug Target and Biomarker for Intractable Pain

Target Name: INTU

NCBI ID: G27152

INTU

INTU: A Potential Drug Target and Biomarker for Intractable Pain

Abstract:

Inturned planar cell polarity effector homolog (INTU) is a gene that has been identified as a potential drug target and biomarker for the treatment of intractable pain. The INTU gene is associated with the production of an enzyme called planar cell polarity (PCP), which plays a crucial role in the development and maintenance of the integrity of neuronal communication. research has shown that individuals with certain genetic variations in the INTU gene are more likely to experience chronic pain, and that these individuals may benefit from interventions that target the regulation of PCP.

Introduction:

Intractable pain is a common condition that can significantly impact an individual's quality of life. Despite advances in pain management, the treatment of intractable pain remains a significant challenge. The INTU gene, which encodes an enzyme involved in the regulation of cell polarity, has been identified as a potential drug target and biomarker for the treatment of this debilitating condition.

The Importance of PCP in Neuronal Communication:

Planar cell polarity (PCP) is a critical regulator of neuronal communication, ensuring that cells maintain the proper structure and function to transmit information. PCP is responsible for the maintenance of the integrity of the cell's plasma membrane, which serves as the boundary between the cell and its environment. The ability of PCP to regulate the movement of positively charged and negatively charged molecules into the cell is essential for maintaining the stability of the cell's membrane and the integrity of its signaling systems.

Mutations in the INTU Gene:

The INTU gene is associated with the production of an enzyme called planar cell polarity (PCP). PCP plays a crucial role in the regulation of neuronal communication and is essential for the development and maintenance of the integrity of the neuronal communication system. Researchers have identified specific genetic variations in the INTU gene that are associated with an increased risk of chronic pain.

The Potential Role of INTU as a Drug Target:

The identification of INTU as a potential drug target and biomarker for the treatment of intractable pain makes it an attractive target for researchers to investigate. By targeting the regulation of PCP,INTU may be able to reduce the production of pain-causing molecules and alleviate symptoms of intractable pain.

The Potential Role of INTU as a Biomarker:

INTU may also serve as a biomarker for the diagnosis and monitoring of intractable pain. The regulation of PCP is known to be involved in the development of chronic pain, and individuals with certain genetic variations in the INTU gene may be more susceptible to chronic pain. By evaluating the levels of PCP and its regulation in individuals with INTU genetic variations, researchers may be able to determine the effectiveness of different treatments for intractable pain.

Conclusion:

INTU is a gene that has been identified as a potential drug target and biomarker for the treatment of intractable pain. The regulation of cell polarity by PCP is a crucial factor in the development and maintenance of the integrity of neuronal communication, and INTU may be a valuable target for the development of new treatments for chronic pain. Further research is needed to fully understand the role of INTU in the treatment of intractable pain and to determine its effectiveness as a biomarker for this debilitating condition.

Protein Name: Inturned Planar Cell Polarity Protein

Functions: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779)

The "INTU Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INTU comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets