Understanding INTS3: A Non-Coding RNA Molecule Regulating DNA Replication

Target Name: INTS3

NCBI ID: G65123

INTS3

Understanding INTS3: A Non-Coding RNA Molecule Regulating DNA Replication

Sensor of ssDNA subunit A (INTS3) is a protein that plays a crucial role in the regulation of DNA replication in eukaryotic cells. It is a key component of the complex DNA replication machinery, which is responsible for copying the genetic information from the DNA template to the new cell. INTS3 is a non-coding RNA molecule that is translated from a protein coding gene and is composed of 19 amino acid residues.

History of INTS3:

The study of DNA replication was first proposed by James Watson and Francis Crick in 1953. They discovered the double helix structure of DNA and proposed that the two complementary strands of DNA were held together by an interaction between their complementary base pairs. This interaction between the base pairs was later named base pairing and is a fundamental principle of genetics.

Over the years, researchers have made significant progress in understanding the mechanisms of DNA replication. INTS3 was first identified in 1995 by researchers led by David Baltimore at the University of California, Berkeley. They demonstrated that INTS3 is a critical component of the DNA replication machinery and that it plays a role in regulating the rate of DNA replication.

Drug Target and Biomarker:

INTS3 has since become a drug target and a potential biomarker for several diseases. Its function in DNA replication makes it an attractive target for drugs that are designed to inhibit DNA replication in cancer cells. Cancer cells have a high rate of DNA replication, which allows them to rapidly divide and spread throughout the body. Therefore, drugs that can inhibit DNA replication in cancer cells are effective in treating cancer.

INTS3 has been shown to be involved in the regulation of multiple cellular processes, including cell growth, apoptosis (programmed cell death), and DNA replication. It has also been shown to play a role in the development and progression of several diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the INTS3 drug targets is the inhibition of INTS3 has been shown to be effective in treating several diseases, including neurodegenerative diseases. INTS3 has been shown to play a role in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Another potential INTS3 drug target is its role in cancer. INTS3 has been shown to be involved in the regulation of DNA replication in cancer cells, which makes it an attractive target for drugs that are designed to inhibit DNA replication in cancer cells.

Biomarker research has also shown that INTS3 levels are elevated in several diseases, including cancer, neurodegenerative diseases, and developmental disorders. This suggests that INTS3 may be a useful biomarker for these diseases and for tracking the effectiveness of INTS3 inhibitors.

Conclusion

INTS3 is a non-coding RNA molecule that plays a crucial role in the regulation of DNA replication in eukaryotic cells. Its function in DNA replication makes it an attractive target for drugs that are designed to inhibit DNA replication in cancer cells. INTS3 has also been shown to play a role in the regulation of multiple cellular processes and in the development and progression of several diseases. Further research is needed to fully understand the role of INTS3 in these processes and to develop effective INTS3 inhibitors for the treatment of INTS3-related diseases.

Protein Name: Integrator Complex Subunit 3

Functions: Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267)

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