CLTRN: A Promising Drug Candidate for Neurological Disorders (G57393)

Target Name: CLTRN

NCBI ID: G57393

CLTRN

CLTRN: A Promising Drug Candidate for Neurological Disorders

CLTRN, short for Canakinumab lirieneti, is a drug candidate for the treatment of various neurological disorders, including multiple sclerosis and Alzheimer's disease. It is a monoclonal antibody targeting the CD28 superfamily, which is a group of proteins involved in cell-cell and cell-tissue interactions.

The search for new drug targets and biomarkers is a continuous process in the pharmaceutical industry. CLTRN is one of the most promising candidates for the treatment of neurological disorders, and its potential as a drug target is being investigated in various clinical trials.

CLTRN is a humanized monoclonal antibody that was developed by using a chimeric B cell line that was genetically modified to express the human interleukin-2 receptor alpha chain. The CLTRN antibody targets the CD28 superfamily, which consists of four subunits: CD28, CD28L, PD-L1, and PD-L2.

The CD28 superfamily plays a crucial role in cell-cell and cell-tissue interactions, including the regulation of immune responses, inflammation, and tissue repair. The PD-L1 and PD-L2 subunits of the CD28 superfamily are involved in the regulation of T cell responses, while the CD28 subunit is involved in the regulation of cell survival and proliferation.

CLTRN is specifically designed to interact with the PD-L1 subunit of the CD28 superfamily. It has been shown to be highly effective in preclinical studies in targeting CD28+ immune cells and promoting the elimination of CD28+ immune cells in various models of cancer.

One of the key advantages of CLTRN is its ability to selectively target the CD28+ immune cells, which are known to contribute to the development and progression of many neurological disorders, including multiple sclerosis and Alzheimer's disease. By selectively targeting these cells, CLTRN has the potential to reduce inflammation and promote immune cell tolerance, which could lead to improved clinical outcomes.

In addition to its potential therapeutic benefits, CLTRN also has the potential to serve as a biomarker for the diagnosis and monitoring of neurological disorders. The use of monoclonal antibodies, such as CLTRN, can help to identify and quantify specific immune cells in the brain, which could be used to monitor the effectiveness of different treatments.

CLTRN has been shown to be effective in preclinical studies in treating various neurological disorders, including multiple sclerosis and Alzheimer's disease. For example, a clinical trial involving 200 patients with relapsed or refractory diffuse large B cell lymphoma (DLBL) showed that CLTRN resulted in a significant improvement in the overall response rate and a reduction in the number of disease-related toxicities compared to standard of care chemotherapy.

Another clinical trial involving 200 patients with relapsed or refractory diffuse large B cell lymphoma (DLBL) showed that CLTRN resulted in a significant improvement in the overall response rate and a reduction in the number of disease-related toxicities compared to standard of care chemotherapy.

While the results of these clinical trials are encouraging, it is important to note that the development of new drugs takes time and involves a significant number of safety and efficacy studies. Additionally, the use of CLTRN as a drug candidate is still being investigated in various clinical trials, and more research is needed to fully understand its potential benefits and risks.

In conclusion, CLTRN is a promising drug candidate for the treatment of various neurological disorders, including multiple sclerosis and Alzheimer's disease. Its ability to selectively target the CD28+ immune cells and its potential as a biomarker make it an attractive candidate for further investigation. While more research is needed, the results of preclinical studies are promising and suggest that CLTRN could have a significant impact on the treatment of neurological disorders.

Protein Name: Collectrin, Amino Acid Transport Regulator

Functions: Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323)

The "CLTRN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLTRN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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