DSCAML1: A Promising Drug Target and Biomarker for Cell Adhesion Molecule-Mediated Diseases

Target Name: DSCAML1

NCBI ID: G57453

DSCAML1

DSCAML1: A Promising Drug Target and Biomarker for Cell Adhesion Molecule-Mediated Diseases

Introduction

The cell adhesion molecule DSCAML1 (doublecortin-like molecule 1) is a key regulator of cell-cell adhesion, which is critical for various physiological processes, including tissue repair, embryonic development, and tissue regeneration. DSCAML1 has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, targeting DSCAML1 has become an attractive research focus in recent years. In this article, we will explore the biology of DSCAML1, its potential as a drug target, and its potential as a biomarker for various diseases.

The biology of DSCAML1

DSCAML1 is a member of the cadherin family, which is a well-established family of transmembrane proteins that play a central role in cell-cell adhesion. The cadherins are characterized by the presence of a transmembrane domain, a cytoplasmic tail, and a N- terminus that contains a unique heptadecapeptide repeat. DSCAML1 is unique in that it has a doublecortin-like domain, which is a conserved region that is involved in the regulation of DNA binding and other cellular processes.

DSCAML1 is primarily expressed in the brain and nervous system, and it is involved in the development and maintenance of neural stem cells, as well as the regulation of neuronal excitability and synaptic plasticity. DSCAML1 has also been shown to be involved in various signaling pathways, including TGF-β, Wnt, andNotch.

DSCAML1 as a drug target

DSCAML1 has emerged as a promising drug target due to its involvement in various diseases. One of the main reasons for its potential as a drug target is its involvement in the regulation of cell-cell adhesion, which is a critical factor in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

DSCAML1 has been shown to play a role in the regulation of cell-cell adhesion in various contexts, including the regulation of cancer cell migration and the development of neurodegenerative diseases. For example, DSCAML1 has been shown to be involved in the regulation of cancer cell migration by tyrosination, a process that is critical for the invasive and metastatic properties of cancer cells.

DSCAML1 has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles and neuroglial cells. DSCAML1 has also been shown to be involved in the regulation of neurodegenerative diseases by regulating the levels of dopamine, a neurotransmitter that is involved in the regulation of mood, appetite, and movement.

DSCAML1 has also been shown to be involved in the regulation of autoimmune disorders, such as rheumatoid arthritis and psoriasis. These conditions are characterized by the development of autoimmune responses that result in inflammation and damage to the body's tissues. DSCAML1 has also been shown to be involved. in the regulation of autoimmune disorders by regulating the production of T cells, a type of immune cell that plays a central role in the regulation of inflammation and autoimmune responses.

DSCAML1 as a biomarker

DSCAML1 has also been shown to be a potential biomarker for various diseases. The development of DSCAML1-targeted therapies has the potential to treat a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the main advantages of DSCAML1 as a biomarker is its potential to be used as a therapeutic target. The development of DSCAML1-targeted therapies has the potential to treat a wide range of diseases

Protein Name: DS Cell Adhesion Molecule Like 1

Functions: Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity)

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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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