HACE1: A Key Player in The Ubiquitin System (G57531)

Target Name: HACE1

NCBI ID: G57531

HACE1

Other Name(s): HECT-type E3 ubiquitin transferase HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1, transcript variant 1 | E3 ubiquitin-protein ligase HACE1 | HACE1 variant 1 | KIAA1320 | SPPRS | E3 ubiquitin-protein ligase HACE1 (isoform a) | HACE1_HUMAN

HACE1: A Key Player in The Ubiquitin System

HACE1, or HECT-type E3 ubiquitin transferase HACE1, is a protein that plays a crucial role in cellular signaling and metabolism. It is a key player in the ubiquitin system, a process by which proteins are modified and degraded by the body's immune system. HACE1 is an enzyme that transfers a ubiquitin tag to the protein p21, which is a key regulator of the cell cycle and a potential drug target in cancer.

HACE1 is a 21-kDa protein that is expressed in most tissues of the body. It is a subunit of the HACE1 complex, which is a protein complex that plays a role in the ubiquitin system. The HACE1 complex consists of two subunits, HACE1 and HACE2, which function together to transfer a ubiquitin tag to target proteins.

HACE1 functions as an enzyme that transfers a ubiquitin tag to the protein p21. P21 is a key regulator of the cell cycle, and it plays a role in preventing the cell from dividing too often. HACE1 transfers a ubiquitin tag to p21, which allows it to be targeted for degradation by the immune system. This is a crucial role for the immune system, as it helps to prevent the growth and spread of cancer cells.

HACE1 is also involved in the regulation of DNA damage repair. When DNA is damaged, the immune system sends a repair team to fix the damage. HACE1 is part of this repair team, and it helps to ensure that the repair process is efficient and effective.

HACE1 is also involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together and form tissues. HACE1 is part of the adhesion molecule JNK, which helps to regulate cell adhesion. This is important for the development and maintenance of tissues and organs.

HACE1 is a potential drug target for cancer. Its role in the ubiquitin system and its involvement in the regulation of cell cycle, DNA damage repair, and cell adhesion make it an attractive target for cancer researchers. HACE1 has been shown to be overexpressed in many types of cancer, including breast, ovarian, and colorectal cancers. This suggests that it may be a useful biomarker for these cancers.

In addition to its potential as a drug target, HACE1 is also a useful tool for studying the ubiquitin system. Its role in the HACE1 complex is the focus of many research studies, and these studies have provided valuable insights into the structure and function of the ubiquitin system.

Overall, HACE1 is a protein that plays a crucial role in the ubiquitin system and is an attractive target for cancer research. Its role in the regulation of cell cycle, DNA damage repair, and cell adhesion makes it an important molecule for understanding the development and progression of cancer. Further research is needed to fully understand the functions of HACE1 and its potential as a drug target.

Protein Name: HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1

Functions: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB

The "HACE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HACE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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