Discovering PYGL: A Protein with Multiple Functions in Metabolism

Target Name: PYGL

NCBI ID: G5836

PYGL

Discovering PYGL: A Protein with Multiple Functions in Metabolism

Phosphorylase, glycogen, and liver are all important molecules in the body that play crucial roles in various physiological processes. Phosphorylase is an enzyme that participates in many metabolic reactions within cells, including cellular respiration and phosphorylation reactions. Glucose is an important source of energy and a substrate for many metabolic reactions in cells. The liver is an important metabolic organ in the human body, responsible for decomposing and synthesizing many important substances.

In recent years, scientists have discovered a number of drug targets related to these three molecules. One of them is PYGL, a protein that works in the liver and intestines.

PYGL is a protein encoded by the PYG gene in the liver. Its main function is to catalyze the phosphorylation reaction. Phosphorylation reaction is an important metabolic process that generates energy and synthesizes important biomolecules within cells. For example, ATP (adenosine triphosphate) is one of the most important energy molecules in cells and is synthesized through a phosphorylation reaction. The phosphorylation reaction of PYGL is crucial to generate ATP in cells.

In addition, PYGL is also related to glycogen synthesis in the liver. Glycogen is an important energy reserve molecule that is synthesized in the liver and muscles. PYGL participates in glycogen synthesis by catalyzing key steps in the glycogen synthesis process.

PYGL also plays an important role in metabolic diseases. For example, genetic variants in PYGL are associated with the risk of liver disease and diabetes. In addition, the expression level of PYGL is also involved in the pathogenesis of fatty liver and alcoholic liver disease.

In addition to its role in the liver and intestines, PYGL is also closely related to the immune system. The expression level of PYGL can reflect the immune response of the liver, and immune response plays a key role in maintaining human health.

As a new drug target, PYGL is of great significance in future research. By developing drugs that can regulate PYGL expression, new ideas can be provided for the treatment of various metabolic diseases.

Protein Name: Glycogen Phosphorylase L

Functions: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

The "PYGL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PYGL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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