Understanding PYM1: Potential Drug Target Or Biomarker (G84305)

Target Name: PYM1

NCBI ID: G84305

PYM1

Understanding PYM1: Potential Drug Target Or Biomarker

PYM1, also known as PYM1 variant 1, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of cell proliferation and has been linked to a number of diseases, including cancer. Despite its importance, little is known about PYM1, including its function and potential as a drug target or biomarker.

PYM1 regulation of cell proliferation

PYM1 is a transcription factor that is involved in the regulation of cell proliferation. It is a key regulator of the G1/S transition, which is the process by which cells prepare for cell division. PYM1 interacts with the transcription factor p21, which is involved in the regulation of cell growth and division.

PYM1 has been shown to play a role in the regulation of cell proliferation by promoting the growth of cancer cells. For example, studies have shown that high levels of PYM1 can promote the growth of breast cancer cells in a culture dish. Additionally, PYM1 has has been shown to promote the development of colon cancer by increasing the growth of cancer cells in a preclinical model.

PYM1's role in cancer progression

The role of PYM1 in cancer progression is not well understood, but it is clear that it is involved in the regulation of cell proliferation and the development of cancer. PYM1 has been shown to promote the growth of cancer cells and to contribute to their survival.

PYM1's potential as a drug target

Despite its involvement in cancer, PYM1 may have potential as a drug target or biomarker. Its role in cell proliferation and the regulation of the G1/S transition makes it a potential target for small molecules that can inhibit its activity. Additionally, its role in the regulation of cell division and its expression in various tissues make it a potential biomarker for monitoring disease progression.

Conclusion

PYM1 is a protein that is expressed in various tissues of the body and is involved in the regulation of cell proliferation. Its role in cancer progression and its potential as a drug target or biomarker make it a promising target for further research. Further studies are needed to fully understand the function and potential of PYM1 and its implications for human health.

Protein Name: PYM Homolog 1, Exon Junction Complex Associated Factor

Functions: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC

The "PYM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PYM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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