Rad51c: A Protein Involved in DNA Replication (G5889)

Target Name: RAD51C

NCBI ID: G5889

RAD51C

Rad51c: A Protein Involved in DNA Replication

Rad51c, also known as RecA-like protein, is a protein that plays a crucial role in the process of DNA replication in bacteria. It is a key component of the replication complex, which is a set of proteins that work together to ensure the accurate replication of DNA in the cell.

RecA is a protein that is highly conserved across different species, and is found in all types of eukaryotic cells. It is involved in the process of DNA replication by binding to the template DNA and ensuring that the correct base is added to the growing strand.

Rad51c is similar to RecA in sequence, but it is expressed in different organisms. In bacteria, Rad51c is found in the Rep protein complex, which is responsible for replicating the DNA in the cell. In mammalian cells, Rad51c is expressed in the Nucleosome I protein complex, which is also responsible for replicating DNA in the cell.

The role of Rad51c in DNA replication is important because it helps ensure that the DNA is replicated accurately and completely. In addition, it is involved in the regulation of the DNA replication process, which is critical for the growth and development of cells.

Research has suggested that Rad51c may be a drug target or biomarker in certain diseases. For example, Rad51c has been shown to be involved in the development of certain types of cancer, such as breast cancer. In addition, studies have suggested that Rad51c may be a useful biomarker for tracking the effectiveness of certain types of cancer treatments.

Another potential application of Rad51c as a drug target is the treatment of neurodegenerative diseases, such as Alzheimer's disease. Research has shown that Rad51c is expressed in the brains of individuals with Alzheimer's disease, and that it is involved in the development and progression of the disease. Therefore, targeting Rad51c with drugs that inhibit its activity may be a promising strategy for the treatment of Alzheimer's disease.

In addition to its potential as a drug target, Rad51c has also been shown to be a useful biomarker for tracking the effectiveness of certain types of cancer treatments. For example, studies have shown that the level of Rad51c in the tumors of individuals who have undergone radiation therapy can be used to predict the effectiveness of the treatment. This suggests that Rad51c may be a valuable biomarker for tracking the response of cancer cells to radiation therapy.

Overall, Rad51c is a protein that plays a crucial role in the process of DNA replication in bacteria and mammalian cells. Its conserved sequence and involvement in the replication complex make it a promising target for drugs and biomarkers. Further research is needed to fully understand the role of Rad51c in DNA replication and its potential as a drug target or biomarker.

Protein Name: RAD51 Paralog C

Functions: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis

The "RAD51C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RAD51C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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