SF3B2: A ProteinCriticallyRegulatedSplicingKeyway (G10992)

Target Name: SF3B2

NCBI ID: G10992

SF3B2

SF3B2: A ProteinCriticallyRegulatedSplicingKeyway

SF3B2 (Pre-mRNA splicing factor SF3b 145 kDa subunit) is a protein that plays a crucial role in the process of splicing, which is the process by which the cell removes non-coding regions from the pre-mRNA and replaces them with coding regions during the process of gene expression. SF3B2 is a subunit of the SF3 protein complex, which is a well-known protein that plays a central role in splicing.

SF3B2 is a 145 kDa protein that is expressed in various tissues and cells throughout the body. It is primarily localized to the nucleus, where it is involved in the regulation of gene expression. SF3B2 is a key player in the process of pre-mRNA splicing, which is the first step in the process of gene expression.

During pre-mRNA splicing, SF3B2 helps to ensure that the correct version of the gene is produced by removing non-coding regions from the pre-mRNA and replacing them with coding regions. This process is critical for the production of functional proteins that are required for various cellular functions.

SF3B2 is a protein that can be targeted by drugs as a potential drug target or biomarker. One way to target SF3B2 is through inhibition of the activity of the SF3 protein complex. This can be done through a variety of methods, including the use of small molecules, antibodies, or genetic modification.

Another approach to targeting SF3B2 is through the use of RNA interference (RNAi) technology. RNAi is a technique that involves the use of small interfering RNA (siRNA) to knockdown the expression of a specific gene. This can be a useful tool for targeting SF3B2 and other proteins that are involved in gene expression.

SF3B2 is also a potential biomarker for a variety of diseases. For example, altered levels of SF3B2 have been observed in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, targeting SF3B2 as a drug target or biomarker could be a promising approach for the development of new treatments for these diseases.

In conclusion, SF3B2 is a protein that plays a crucial role in the process of splicing and is a potential drug target or biomarker. The use of small molecules, antibodies, or RNA interference technology can be used to target SF3B2 and its activity in gene expression. Further research is needed to fully understand the role of SF3B2 in splicing and its potential as a drug target or biomarker.

Protein Name: Splicing Factor 3b Subunit 2

Functions: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable)

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•   general information;
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•   expression level;
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