SF3B1 Regulates Splicing and Gene Expression in Cancer (G23451)

Target Name: SF3B1

NCBI ID: G23451

SF3B1

SF3B1 Regulates Splicing and Gene Expression in Cancer

Splicing factor 3b subunit 1 (SF3B1) is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in cancer. It is a key player in the process of splicing, which is the process by which the cell removes non -coding regions from the RNA molecule and joins together the remaining coding regions to create a functional protein.

SF3B1 is a protein that contains 116 amino acids and has been shown to play a role in the regulation of splicing in various tissues and organs. It is expressed in a variety of tissues, including the brain, heart, and gastrointestinal tract, and has been shown to be involved in the development and progression of several diseases, including cancer.

One of the key functions of SF3B1 is its role in the regulation of pre-mRNA splicing. Pre-mRNA splicing is a process by which the cell removes non-coding regions from the RNA molecule and joins together the remaining coding regions to create a functional protein. This process is critical for the development of functional proteins and is involved in the regulation of many different cellular processes.

SF3B1 has been shown to play a role in the regulation of pre-mRNA splicing by interacting with the protein splicer. splicer is a protein that recognizes specific sequences in the pre-mRNA and cuts the RNA at those sites. SF3B1 has been shown to interact with splicer and prevent it from cutting the RNA, which allows for the efficient regulation of pre-mRNA splicing.

Another function of SF3B1 is its role in the regulation of post-mRNA splicing. Post-mRNA splicing is a process by which the cell removes the non-coding regions from the RNA molecule and joins together the remaining coding regions to create a functional RNA molecule . This process is also critical for the development of functional proteins and is involved in the regulation of many different cellular processes.

SF3B1 has been shown to play a role in the regulation of post-mRNA splicing by interacting with the protein tranScriptase. TranScriptase is a protein that recognizes specific sequences in the RNA molecule and cuts the RNA at those sites. SF3B1 has been shown to interact with tranScriptase and prevent it from cutting the RNA, which allows for the efficient regulation of post-mRNA splicing.

In addition to its role in the regulation of splicing, SF3B1 has also been shown to play a role in the regulation of gene expression. It has been shown to interact with the protein MyB protein and prevent it from binding to the DNA, which allows for the efficient regulation of gene expression.

Furthermore, SF3B1 is also involved in the regulation of cellular processes that are important for the development and progression of cancer. For example, it has been shown to play a role in the regulation of cell cycle progression, which is the process by which cells grow , divide, and replicate themselves.

SF3B1 is also involved in the regulation of angiogenesis, which is the process by which new blood vessels form in the body. This process is critical for the development and progression of cancer, and SF3B1 has been shown to play a role in its regulation.

In conclusion, SF3B1 is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in cancer. It is a key player in the process of splicing, which is the process by which the cell removes non-coding regions from the RNA molecule and joins together the remaining coding regions to create a functional protein. SF3B1 is involved in the regulation of pre-mRNA splicing and post-mRNA splicing and also it plays a role in the regulation of gene expression, cellular processes, and the development

Protein Name: Splicing Factor 3b Subunit 1

Functions: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable)

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