IL-8: A Protein Involved in A Wide Range of Biological Processes That Is Potential Drug Target
IL-8: A Protein Involved in A Wide Range of Biological Processes That Is Potential Drug Target
CCL8 (MCP2), also known as interleukin-8 (IL-8), is a protein that is expressed in a variety of tissues throughout the body. It is a cytokine, which means it is a signaling molecule that is released by cells in response to specific stimuli. One of the things that makes IL-8 such a potential drug target is its ability to interact with a wide range of proteins, including cell surface receptors. This makes it a promising target for the development of new treatments for a variety of diseases.
IL-8 is involved in many different signaling pathways in the body. One of the most well-studied functions of IL-8 is its role in the immune system. When the body is exposed to an infection, IL-8 is released by white blood cells in response to the infection. This helps the body to fight off the infection and to protect itself from further harm. IL-8 is also involved in the regulation of inflammation, which is a critical part of the immune response.
Another function of IL-8 is its role in cell signaling. IL-8 can interact with a wide range of cell surface receptors, including those on cancer cells. This makes it a potential target for the development of new treatments for cancer. The ability of IL-8 to interact with these receptors makes it an attractive candidate for the development of cancer vaccines, which can help to stimulate an immune response against cancer cells.
IL-8 is also involved in the regulation of cell growth and differentiation. It can induce the growth of cancer cells and can also contribute to the development of cancer by promoting the survival and proliferation of pre-existing cancer cells. The ability of IL-8 to promote cancer growth makes it a potential target for the development of anti-cancer drugs that can inhibit its activity.
In addition to its role in cancer, IL-8 is also involved in a number of other biological processes that are important for human health. For example, it is involved in the regulation of pregnancy and fetal development. It is thought to play a key role in the development and maintenance of pregnancy, and is downregulated in the body after pregnancy. The loss of IL-8 function in pregnancy has been linked to a number of reproductive and developmental disorders, including miscarriage, preterm delivery, and developmental delays. The potential use of IL-8 as a drug target makes it a promising target for the development of treatments for a range of reproductive and developmental disorders.
Another function of IL-8 is its role in the regulation of pain. IL-8 is involved in the production of pain signals in the body, and is thought to play a key role in the development of chronic pain. The ability of IL-8 to interact with pain receptors makes it a potential target for the development of pain medications.
In addition to its role in pain and cancer, IL-8 is also involved in a number of other biological processes that are important for human health. It is involved in the regulation of inflammation, which is a critical part of the immune response. The failure of IL-8 to function properly in the immune system has been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. The potential use of IL-8 as a drug target makes it a promising target for the development of treatments for these and other autoimmune diseases.
IL-8 is also involved in the regulation of skin health. It is thought to play a key role in the development and maintenance of healthy skin, and is downregulated in the skin in response to environmental stressors. The loss of IL-8 function in the skin has been linked to a number of skin disorders, including dry skin, eczema, and psoriasis. The potential use of IL-8 as a drug target makes it a promising target for the development of treatments for these and other skin disorders.
In addition to its role in
Protein Name: C-C Motif Chemokine Ligand 8
Functions: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8
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More Common Targets
CCM2 | CCM2L | CCN1 | CCN2 | CCN3 | CCN4 | CCN5 | CCN6 | CCNA1 | CCNA2 | CCNB1 | CCNB1IP1 | CCNB2 | CCNB2P1 | CCNB3 | CCNC | CCND1 | CCND2 | CCND2-AS1 | CCND3 | CCNDBP1 | CCNE1 | CCNE2 | CCNF | CCNG1 | CCNG2 | CCNH | CCNI | CCNI2 | CCNJ | CCNJL | CCNK | CCNL1 | CCNL2 | CCNO | CCNP | CCNQ | CCNQP1 | CCNT1 | CCNT2 | CCNT2-AS1 | CCNT2P1 | CCNY | CCNYL1 | CCNYL2 | CCP110 | CCPG1 | CCR1 | CCR10 | CCR12P | CCR2 | CCR3 | CCR4 | CCR4-NOT transcription complex | CCR5 | CCR5AS | CCR6 | CCR7 | CCR8 | CCR9 | CCRL2 | CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E
