Target Name: CCR6
NCBI ID: G1235
Review Report on CCR6 Target / Biomarker Content of Review Report on CCR6 Target / Biomarker
CCR6
Other Name(s): C-C motif chemokine receptor 6 | C-C CKR-6 | CCR6 variant 1 | LARC receptor | chemokine (C-C) receptor 6 | GPRCY4 | chemokine (C-C motif) receptor 6 | CD196 | seven-transmembrane receptor, lymphocyte, 22 | DRY6 | C-C chemokine receptor type 6 | G protein-coupled receptor 29 | CKR6 | DRY-6 | GPR29 | Seven-transmembrane receptor, lymphocyte, 22 | CKR-L3 | G-protein coupled receptor 29 | chemokine receptor-like 3 | CMKBR6 | BN-1 | DCR2 | CKRL3 | Chemokine (C-C) receptor 6 | CCR6_HUMAN | C-C motif chemokine receptor 6, transcript variant 1 | STRL22 | CCR-6 | CCR6 variant 2 | GPR-CY4 | C-C motif chemokine receptor 6, transcript variant 2 | Chemokine receptor-like 3 | CC-CKR-6

CCR6: A Multi-Functional Receptor for Chemicals and Pain

CCR6 (C-C motif chemokine receptor 6) is a protein that is expressed in a variety of tissues throughout the body. It is a member of the chemokine receptor family, which is a group of transmembrane proteins that play a crucial role in the regulation of cellular immune responses. CCR6 is one of the most well-studied chemokine receptors, and is a potential drug target and biomarker.

CCR6 was first identified in the 1990s as a cell surface protein that was able to interact with certain chemokines, which are small proteins that are released by cells in response to the presence of foreign substances like viruses or cancer cells. Chemoattractants, as they are called, can bind to CCR6 and cause it to become tyrosinated, which is a chemical modification that can modulate the activity of the protein.

The CCR6 receptor is a member of the superfamily of G protein-coupled receptors (GPCRs), which are a family of transmembrane proteins that are involved in a wide range of cellular processes. GPCRs are characterized by their ability to modulate the activity of intracellular signaling pathways, including the cAMP/cGMP signaling pathway. This pathway is involved in the regulation of many different cellular processes, including the immune response, cell growth, and metabolism.

Studies have shown that CCR6 is involved in the regulation of both the cell division and the immune response. In addition, CCR6 has been shown to play a role in the regulation of pain perception and neuroinflammation.

As a potential drug target, CCR6 is an attractive target for drug developers because of its involvement in multiple cellular processes that are important for human health and disease. In addition, CCR6 is a good candidate for a biomarker because it is a protein that is expressed in many different tissues and cells, which makes it easy to detect and measure.

One of the challenges in studying CCR6 is its high degree of expression. CCR6 is expressed in many different tissues and cells throughout the body, which makes it difficult to study its effects in specific contexts. Additionally, CCR6 is a protein that is involved in multiple cellular processes, which can make it difficult to understand how it functions in different settings.

Despite these challenges, researchers have made significant progress in the study of CCR6. For example, studies have shown that inhibiting the activity of CCR6 can have a variety of different effects, including the inhibition of cell division, the regulation of pain perception, and the modulation of neuroinflammation. In addition, researchers have developed several potential small molecules that can inhibit the activity of CCR6 and are in the process of testing them as potential drug candidates.

Another potential application of CCR6 is as a biomarker. Because CCR6 is expressed in many different tissues and cells, it is a protein that can be used to diagnose and monitor a wide range of diseases. For example, CCR6 has been shown to be involved in the regulation of cancer cell growth and has been used as a biomarker for cancer diagnosis and treatment. In addition, CCR6 has been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, which makes it a potential biomarker for these conditions as well.

In conclusion, CCR6 is a protein that is involved in multiple cellular processes and is a potential drug target and biomarker. Its high degree of expression and involvement in multiple processes make it a promising target for drug development, and its involvement in the regulation of pain perception and neuroinflammation make it a potential biomarker for a wide range of diseases. Further research is needed to fully understand the role of CCR6 in cellular processes and its potential as a drug

Protein Name: C-C Motif Chemokine Receptor 6

Functions: Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988)

The "CCR6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCR6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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