Target Name: CCN4
NCBI ID: G8840
Review Report on CCN4 Target / Biomarker Content of Review Report on CCN4 Target / Biomarker
CCN4
Other Name(s): CCN4 variant 1 | WISP1-UT1 | WISP1-OT1 | WISP1tc | WISP1c | WISP1 | WNT1-inducible-signaling pathway protein 1 | WNT1 inducible signaling pathway protein 1 (WISP-1) | WNT1 inducible signaling pathway

Potential Cancer Treatment Target: CCN4

Cancer-associated neovascularization (CAV) is a hallmark feature of cancer growth and progression. CAVs are networks of vessels that develop in the tumor microenvironment and are involved in the delivery of oxygen, nutrients, and other therapeutic agents to the tumor cells. The The development and maintenance of CAVs is a key factor in cancer progression and has been identified as a potential therapeutic target for cancer treatment.

CCN4 (Cancer-associated neoangiogenesis) is a protein that has been identified as a potential drug target for cancer treatment. CCN4 is a cytoplasmic protein that is expressed in a variety of tissues, including cancer cells, and is involved in the formation and function of CAVs.

structure

CCN4 is a 21-kDa protein that consists of a unique N-terminus, a catalytic C-terminus, and a C-terminal hypervariable region (HVR). The N-terminus of CCN4 contains a unique farnesylated cysteine 鈥嬧?媟esidue, which is important for protein stability and functions as a critical modifier of the protein's stability and localization. The catalytic C-terminus of CCN4 contains a unique lysine residue that is important for protein-protein interactions and functions as a critical modifier of the protein's stability and localization. The C -terminal HVR of CCN4 contains a unique acidic amino acid residue that is important for protein stability and functions as a critical modifier of the protein's stability and localization.

Expression

CCN4 is expressed in a variety of tissues, including cancer cells, and is involved in the formation and function of CAVs. Studies have shown that CCN4 is highly expressed in a variety of cancer types, including breast cancer, lung cancer, and colorectal cancer. CCN4 is also expressed in normal tissues, including blood vessels, fat tissue, and mucous membranes.

Function

CCN4 is involved in the formation and function of CAVs, which are networks of vessels that develop in the tumor microenvironment and are involved in the delivery of oxygen, nutrients, and other therapeutic agents to the tumor cells. The development and maintenance of CAVs is a key factor in cancer progression, and the deregulation of CAVs has been identified as a potential therapeutic target for cancer treatment.

Research shows that CCN4 is involved in the formation and function of CAVs by regulating the formation of new vasculature, the growth and maintenance of existing vasculature, and the recruitment of new blood vessels to the tumor. CCN4 has been shown to play a role in the development of new blood vessels in tumors, and is involved in the regulation of angiogenesis, the formation of new blood vessels, and the delivery of oxygen and nutrients to the tumor cells.

Mechanism

CCN4 is involved in the formation and function of CAVs by regulating the formation of new vasculature, the growth and maintenance of existing vasculature, and the recruitment of new blood vessels to the tumor. CCN4 has been shown to play a role in the development of new blood vessels in tumors, and is involved in the regulation of angiogenesis, the formation of new blood vessels, and the delivery of oxygen and nutrients to the tumor cells.

Research result

Research shows that CCN4 is involved in the regulation of angiogenesis, the formation of new blood vessels, and the delivery of oxygen and nutrients to the tumor cells. CCN4 has been shown to play a role in the development of new blood vessels in tumors and is Involved in the regulation of angiogenesis, the formation of new blood vessels, and the delivery of oxygen and nutrients to the tumor cells.

Application prospects

CCN4 is a potential drug target for cancer treatment because of its involvement in the regulation of angiogenesis, the formation of new blood vessels, and the delivery of oxygen and nutrients to the tumor cells. Studies have shown that CCN4 is highly expressed in a variety of cancer types, including breast cancer, lung cancer, and colorectal cancer, and is also expressed in normal tissues, such as blood vessels, fat tissue, and mucous membranes. The de

Protein Name: Cellular Communication Network Factor 4

Functions: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan

The "CCN4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCN4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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