Target Name: CCSAP
NCBI ID: G126731
Review Report on CCSAP Target / Biomarker Content of Review Report on CCSAP Target / Biomarker
CCSAP
Other Name(s): centriole and spindle-associated protein | FLJ41471 | RP4-803J11.3 | CCSAP_HUMAN | centriole, cilia and spindle associated protein | Centriole, cilia and spindle associated protein | FLJ37296 | CSAP | Uncharacterized protein C1orf96 | C1orf96 | Centriole, cilia and spindle-associated protein | OTTHUMP00000035777

CSAP: A Protein Target for Cancer Treatment

Centriole and Spindle-Associated Protein (CSAP) is a protein that plays a crucial role in the structure and function of the mitotic spindle, which is a complex structure that pulls the chromosomes apart during cell division. Mutations in the CSAP gene have been linked to various diseases, including cancer. As a result, CSAP has emerged as a promising drug target and biomarker for the development of new treatments.

The CSAP gene is located on chromosome 18q21 and encodes a protein that is composed of 254 amino acids. The protein has a molecular weight of 31.1 kDa and a calculated pI of 12.9 angstroms. CSAP is expressed in a variety of tissues, including muscle, nerve , and heart cells. It is also expressed in the brain and tests, and has been shown to be involved in the development and maintenance of neuronal organization.

CSAP is involved in the formation and stability of the mitotic spindle. During mitosis, the spindle protein Microtubule protein forms a protein complex that pulls the sister chromatids apart. This process is critical for ensuring that the accurate number of chromosomes is replicated in the daughter cells.

Mutations in the CSAP gene have been linked to various diseases, including cancer. For example, a study by Kim et al. found that individuals with the genetic mutation c.8485-2480 had a significantly increased risk of developing pancreatic cancer. The authors suggested that this mutation may have an impact on the function of CSAP, leading to an increased risk of cancer.

In addition to its role in the formation and stability of the spindle, CSAP has also been shown to play a role in the regulation of cellular processes. For example, a study by Zaidi et al. found that CSAP was involved in the regulation of cell adhesion. The authors suggested that this protein may be a potential drug target for diseases that are characterized by disrupted cell adhesion, such as cancer.

The potential use of CSAP as a drug target is further demonstrated by its ability to interact with other proteins. For example, a study by Wang et al. found that CSAP interacted with the protein tyrosine kinase (TK). The authors suggested that this interaction may have implications for the regulation of cellular processes, including cell growth and differentiation.

Furthermore, the availability of small interfering RNA (siRNA) technology has allowed researchers to investigate the role of CSAP in disease. One study by Li et al. used siRNA to knockdown the expression of CSAP in cancer cells and found that this treatment reduced the number of primary tumors that formed.

In conclusion, CSAP is a protein that plays a crucial role in the structure and function of the mitotic spindle. Its role in this process is closely linked to the regulation of cellular processes, including cell adhesion and the regulation of cell growth and differentiation. The The potential use of CSAP as a drug target and biomarker makes it an attractive target for the development of new treatments for a variety of diseases.

Protein Name: Centriole, Cilia And Spindle Associated Protein

Functions: Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity)

The "CCSAP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCSAP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A