M4A4E: A Mitochondrial Protein Involved in Various Diseases (G643680)

Target Name: MS4A4E

NCBI ID: G643680

MS4A4E

Other Name(s): M4A4E_HUMAN | membrane spanning 4-domains A4E | Putative membrane-spanning 4-domains subfamily A member 4E | Hypothetical protein LOC643680 | Putative membrane-spanning 4-domains subfamily A member 4E isoform 1 | Membrane-spanning 4-domains, subfamily A, member 4E, transcript variant 3 | MS4A4E variant X2 | MS4A4E variant 3 | Membrane spanning 4-domains A4E, transcript variant 1 | Membrane spanning 4-domains A4E, transcript variant X2 | MS4A4E variant 1 | Membrane-spanning 4-domains, subfamily A, member 4E (isoform 3)

M4A4E: A Mitochondrial Protein Involved in Various Diseases

MS4A4E (M4A4E_HUMAN) is a protein that is expressed in various tissues of the human body, including the nervous system, endothelial cells, and various immune cells. Its full name is mitochondrial protein 4A4 (Mitochondrial Protein 4A4), and it is a member of the Mitochondrial Complex (Mitochondrial Complex I) protein family.

The M4A4E protein is a 21-kDa protein that is expressed in the brain, spinal cord, heart, and various other tissues of the body. It is highly conserved and has a similar structure to other M4A4 proteins, which are known to be involved in various cellular processes, including mitochondrial function, energy metabolism, and signaling pathways.

One of the key functions of M4A4E is its role in regulating mitochondrial dynamics and metabolism. M4A4E is a protein that is involved in the assembly and disassembly of mitochondrial organelles, such as the mitochondrial protein importin (MTI) and the mitochondrial protein translocation factor (MTF2), which are involved in importing and exporting proteins into the mitochondria.

In addition to its role in regulating mitochondrial dynamics, M4A4E is also involved in the regulation of cellular signaling pathways. It has been shown to be involved in a variety of signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

M4A4E has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that M4A4E is overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer. This overexpression is thought to contribute to the development and progression of these diseases.

Furthermore, M4A4E has also been shown to be a potential drug target in the treatment of various diseases. For example, studies have shown that M4A4E is involved in the regulation of cellular signaling pathways, including the TGF-β pathway, which is involved in cell growth, survival, and angiogenesis. Therefore, inhibitors of the TGF-β pathway have been shown to be effective in the treatment of various diseases, including cancer.

In conclusion, M4A4E (M4A4E_HUMAN) is a protein that is involved in various cellular processes in the body, including the regulation of mitochondrial dynamics and metabolism, and the regulation of cellular signaling pathways. Its full name is mitochondrial protein 4A4, and it is a member of the Mitochondrial Complex (Mitochondrial Complex I) protein family. M4A4E has been shown to play a role in the development and progression of various diseases, including cancer, and it has also been shown to be a potential drug target for the treatment of these diseases. Therefore, further research is needed to fully understand the role of M4A4E in the treatment of various diseases.

Protein Name: Membrane Spanning 4-domains A4E

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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