Target Name: MTFR1
NCBI ID: G9650
Review Report on MTFR1 Target / Biomarker Content of Review Report on MTFR1 Target / Biomarker
MTFR1
Other Name(s): KIAA0009 | Mitochondrial fission regulator 1 (isoform 3) | MTFR1 variant 3 | mitochondrial fission regulator 1 | Mitochondrial fission regulator 1, transcript variant 3 | MTFR1_HUMAN | chondrocyte protein with a poly-proline region | Mitochondrial fission regulator 1 | CHPPR | FAM54A2 | Chondrocyte protein with a poly-proline region

MTFR1: A Protein Involved in Many Cellular Processes

MTFR1 (KiAA0009) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and intestine. It is a member of the superfamily of transmembrane protein (SMP) and is characterized by the presence of a catalytic active site and a hydrophobic region.

MTFR1 is involved in many different cellular processes in the body, including the regulation of ion and water transport, cell signaling, and neurotransmitter release. It is a key regulator of the blood-brain barrier (BBB), which is a specialized barrier that separates the brain from the surrounding blood vessels and is designed to protect the brain from harmful substances.

One of the unique features of MTFR1 is its ability to form a complex with other proteins, including the neurotransmitter acetylcholine (ACh) and the ion channel K+ channels. This interaction between MTFR1 and ACh is critical for the regulation of neuronal excitability and for the development of neurotransmitter-dependent behaviors.

MTFR1 is also involved in the regulation of ion transport across the membrane of various tissues, including the regulation of sodium (Na+) and potassium (K+) channels. This regulation is critical for maintaining the resting membrane potential of cells and for the proper functioning of many different cellular processes.

In addition to its role in ion and water transport, MTFR1 is also involved in the regulation of cell signaling. It is a structural component of several different signaling pathways, including the G-protein-coupled receptor (GPCR) signaling pathway and the neurotransmitter signaling pathway.

MTFR1 is also a key regulator of neurotransmitter release. It is involved in the regulation of the release of several neurotransmitters, including dopamine (DOP), serotonin (5-HT), and nitric oxide (NO). This regulation is critical for the proper functioning of many different neural circuits and for the regulation of mood, appetite, and other physiological processes.

In addition to its involvement in neurotransmitter release, MTFR1 is also involved in the regulation of cell adhesion. It is a structural component of the tight junction protein (TJP), which is responsible for the regulation of cell-cell adhesion. This regulation is critical for the proper functioning of many different tissues, including the blood vessels, the epithelial tissue, and the connective tissue.

MTFR1 is also involved in the regulation of inflammation. It is a structural component of several different signaling pathways that are involved in the regulation of inflammation, including the production of pro-inflammatory cytokines and the regulation of the immune response.

In conclusion, MTFR1 is a protein that is involved in many different cellular processes in the body. Its unique ability to form a complex with other proteins, including neurotransmitters and ion channels, makes it an attractive drug target for researchers interested in the regulation of neuronal excitability and other physiological processes. Further research is needed to fully understand the role of MTFR1 in the regulation of cellular processes and to develop effective therapies based on this protein.

Protein Name: Mitochondrial Fission Regulator 1

Functions: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity)

The "MTFR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTFR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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