MTF1: A Potential Drug Target for Various Diseases (G4520)

Target Name: MTF1

NCBI ID: G4520

MTF1

MTF1: A Potential Drug Target for Various Diseases

MTF1 (Mesothelin Targeting Receptor 1) is a protein that is expressed in various tissues throughout the body, including the skin, lungs, kidneys, and gastrointestinal tract. It is a transmembrane glycoprotein that consists of an extracellular portion and an intracellular portion. The extracellular portion of MTF1 is involved in cell-cell adhesion and tissue-tissue interactions, while the intracellular portion is involved in cell signaling and survival.

MTF1 has been identified as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and various functions have made it an attractive target for researchers to study and develop new treatments.

One of the main reasons for the interest in MTF1 is its ability to interact with various cell signaling pathways. MTF1 has been shown to interact with several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These interactions are important for the regulation of cell growth, differentiation, and survival.

MTF1 has also been shown to play a role in the development and progression of various diseases. For example, MTF1 has been shown to be overexpressed in various types of cancer, including breast, ovarian, and prostate cancer. This overexpression is thought to contribute to the development and progression of these diseases. Additionally, MTF1 has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Another reason for the interest in MTF1 is its role in tissue repair and regeneration. MTF1 has been shown to be involved in the regulation of cell proliferation and differentiation, as well as the formation of new tissues during wound healing and tissue regeneration.

MTF1 has also been shown to play a role in the regulation of pain and inflammation. For example, MTF1 has been shown to interact with the nociceptive system, which is responsible for the sensation of pain. This interaction suggests that MTF1 may be involved in the regulation of pain signaling. Additionally, MTF1 has also been shown to interact with the immune system, which is involved in the regulation of inflammation and immune responses.

In conclusion, MTF1 is a protein that has various functions in the body, including cell-cell adhesion, tissue-tissue interactions, and signaling pathways. Its unique structure and interactions with other proteins make it an attractive target for drug development. Further research is needed to fully understand the role of MTF1 in various diseases and to develop new treatments.

Protein Name: Metal Regulatory Transcription Factor 1

Functions: Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity)

The "MTF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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